Comparison between Liquid-based Cytology and Conventional Exfoliative Cytology in the Diagnosis of Head and Neck Carcinomas

Eduardo Bauml Campagnoli, Rodrigo Sandrin, Beatriz Helena Sottile França, Laurindo Moacir Sassi, Maria Ângela Naval Machado, Antonio Adilson Soares de Lima

Abstract


Objective: To compare the liquid-based cytology and conventional exfoliative cytology in the diagnosis of head and neck carcinomas.
Methods: One hundred and two slides obtained from 19 individual with malignant neoplasias were examined. The samples were divided into 3 groups: group 1 - head and neck carcinoma smears obtained by liquid-based cytology; group 2 (control) - liquid-based cytology samples obtained from healthy tissue (opposed anatomic region), and group 3 - head and neck carcinoma smears obtained by conventional exfoliative cytology. The smears were processed in laboratory and evaluated by light microscopy. Data were subjected to the chi-square (X2), ANOVA and Tukey-Kramer test (p<0.05).
Results: There was statistically significant difference (p<0.05) among the groups for the cellular alterations suggestive of malignancy. The slides prepared by liquid-based cytology permitted better visualization of the neoplastic cells. The epithelial cells were more dissociated and the sample was more representative. The number of unsatisfactory samples decreased by 54.6% and the sensitivity increased by 53% when liquid-based cytology was used. This technique permitted obtaining more homogeneous smears and slides with better quality, reducing the number of unsatisfactory samples and increasing the sensitivity of the exam.
Conclusion: Liquid-based cytology can be indicated as an auxiliary resource in the diagnosis of oral lesions, especially in the cases of malignant neoplasias of epithelial origin.

Keywords


Citologia; Neoplasias bucais; Diagnóstico bucal; Mucosa bucal; Cytology; Mouth neoplasms; Oral diagnosis; Mouth mucosa.



DOI: http://dx.doi.org/10.4034/pboci.v11i1.1257

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