Effect of Scaling and Root Planing Treatment on Levels Hs-CRP in Indonesian Patients with Risk of Cardiovascular Disease

Rasmidar Samad, Fuad Husain Akbar, Olivia Angreani Willianto, Qushay Umar Malinta, Hanna Aulia Namirah


Objective: To determine the effect of scaling and root planning treatment on levels of hs-CRP (C-reactive protein) in patients with risk of cardiovascular disease. Material and Methods: This research is an experimental research with one group pre- and post-test design. This research was performed to the periodontal patients who came to the clinic and have risk of cardiovascular disease. Medical evaluations included measurement of blood pressure and body mass index were performed. Blood samples were obtained from each subject after over night fasting, high-sensitivity C-reactive protein was measured as an index of inflammation. Blood samples were analysed two times before treatment (scaling and root planning) and three weeks later. Statistical analysis used Paired t-test. The level of significance was set at 5%. Results: Means-CRP levels before and after treatment in scaling and root planning were 3.16 ± 2.37 and 2.18±1.56 (p=0.007). Conclusion: There are significant differences between hs-CRP levels before and after treatment.


Cardiovascular Diseases; Dental Scaling; Root Planing; C-Reactive Protein.

Full Text:



Wangsarahardja K. Periodontal disease as a risk factor for coronary heart disease. Universa Medicina 2005; 24(3):136-44.

Lindhe J. Clinical Periodontology and Implant Dentistry. 4th. ed. Munksgaard: Blackwell; 2003. p. 370-375.

Samad R. Periodontitis and Risk of Coronary Heart Disease. Bogor: IPB Press; 2012. p. 24-28.

Glurich I, Grossi S, Albini B, Ho A, Shah R, Zeid M, et al. Systemic inflammation in cardiovascular and periodontal disease: Comparative study. Clin Diagn Lab Immunol 2002; 9(2):425-32. https://doi.org/10.1128/CDLI.9.2.425-432.2002

Li X, Kolltveit KM, Tronstad L, Olsen I. Systemic disease caused by oral infection. Clin Microbiol Rev 2000; 13(4):547-58.

Rose LF, Mealey BL. Periodontics: Medicine, Surgery and Implants. Saint Louis: Elsevier Mosby; 2004. p. 847-851.

Mealey BL, Perry RK. Periodontal medicine: Impact of Periodontal Infection on Systemic Health. In: Carranza's Clinical Periodontology. 10th. ed. Philadelphia: W. B. Saunder Company; 2006. p. 70-76.

Manson JD, Eley BM. Periodontics. 5th. ed. Edinburgh: Elsevier; 2004. p. 33-45.

Kinane DF. Periodontal diseases contributions to cardiovascular disease: An overview of potential mechanisms. Ann Periodontol 1998; 3(1):142-50. https://doi.org/10.1902/annals.1998.3.1.142

Beck J, Garcia R, Heiss G, Vokonas PS, Offenbacher S. Periodontal diseases and cardiovascular disease. J Periodontol 1996; 67(10 Suppl):1123-37. https://doi.org/10.1902/jop.1996.67.10s.1123

Suryaatmadja M. Role of Hs-CRP and cholesterol examination in the prevention of cardiovascular disease. Available from: http://www.abclab.co.id/?p=847. [Accessed 14 July 2014]

Bartova J, Sommerova P, Lyuya-mi Y, Mysak J, Prochazkova J, Duskova J, et al. Periodontitis as a risk factor of atherosclerosis. J Immunol Res 2014; Article ID 636893. https://doi.org/10.1155/2014/636893

Benedek T. The link between periodontal disease, inflammation and atherosclerosis – An interdisciplinary Approach. J Interdisc Med 2017; 2(1):11-6. https://doi.org/10.1515/jim-2017-0016

Ziganshina EE, Sharifullina DM, Lozhkin AP, Khayrullin RN, Ignatyev IM, Ziganshin AM. Bacterial communities associated with atherosclerotic plaques from Russian individuals with atherosclerosis. PLoS One 2016; 11(10):e0164836. https://doi.org/10.1371/journal.pone.0164836

Leishman SJ, Do HL, Ford PJ. Cardiovascular disease and the role of oral bacteria. J Oral Microbiol 2010; 2:5781. https://doi.org/10.3402/jom.v2i0.5781

Maekawa T, Takahashi N, Tabeta K, Aoki Y, Miyashita H, Miyauchi S, et al. Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile. PLoS One 2011; 6(5):e20240. https://doi.org/10.1371/journal.pone.0020240

D'Aiuto F, Parkar M, Andreaou G, Brett PM, Ready D, Tonetti MS. Periodontitis and atherogenesis: Causal association or simple coincidence?. J Clin Periodontol 2004; 31(5):402-11. https://doi.org/10.1111/j.1600-051X.2004.00580.x

Bale BF, Doneen AL, Vigerust DJ. High-Risk periodontal pathogens contribute to the pathogenesis of atherosclerosis. Postgrad Med J 2017; 93(1098):215-20. https://doi.org/10.1136/postgradmedj-2016-134279

Leite AC, Carneiro VM, Guimarães M do C. Effects of periodontal therapy on C-reactive protein and HDL in serum of subjects with periodontitis. Rev Bras Cir Cardiovasc 2014; 29(1):69-77. https://doi.org/10.5935/1678-9741.20140013

Gomes-Filho IS, Freitas Coelho JM, Cruz SS, Passos JS, Teixeira de Freitas CO, Aragão Farias NS, et al. Chronic periodontitis and C-reactive protein levels. J Periodontol 2011; 82(7):969-78. https://doi.org/10.1902/jop.2010.100511

De Maat MP, Kluft C. Determinants of C-reactive protein concentration in blood. Ital Heart J 2001; 2(3):189-95.

Arumalla VK, Kathyaini R. Serum high sensitivity C-reactive protein in different grades of obesity. Res J Pharm Biol Chem Sci 2011; 2(4):1041-6.

Budiono D, Kaligis SHM, Assa YA. Association of low-density lipoprotein levels with level of high sensitivity C-reactive protein in obese adolescents. J e-Biomed 2014; 2(1):1-7.

DOI: http://dx.doi.org/10.4034/PBOCI.2019.191.02