Compatibility of Clinical and Histopathological Diagnosis of Oral Lesions in Iranian Patients

Parya Emamverdizadeh, Seyed Ahmad Arta, Milad Ghanizadeh, Ramin Negahdari, Mohamad Ali Ghavimi, Arezo Ghoreishizadeh, Mohamad Reza Tojih


Objective: To determine compatibility between clinical diagnosis and the pathological reports of biopsies from oral lesions. Material and Methods: In this descriptive study, 1146 clinical files of patients referring to Tabriz Faculty of Dentistry from 2004 to 2016 were retrieved and evaluated. The kappa coefficient was calculated for each file for compatibility of clinical and pathological diagnosis. Results: In relation to clinical (40.2%) and pathological (39.2%) diagnosis, irritational lesions of soft tissues exhibited the highest frequency. In 72.3% of cases, the clinical and pathological diagnosis were compatible and in 27.7% of cases these diagnosis were not compatible. The highest compatibility rates were detected for irritational lesions of soft tissues (81.5%) and mucocutaneous lesions (76.9%). There was no compatibility for osseous malignant tumors, inflammatory tissues, granulation tissues, metastatic lesions and hematologic disorders. Conclusion: Approximately one-third of clinical and histopathological diagnosis were not compatible. Therefore, to reach a correct diagnosis, the clinical, radiographic and histopathological views should be evaluated simultaneously.


Diagnosis, Oral; Mouth Neoplasms; Clinical Laboratory Techniques.

Full Text:



Shulman JD. Prevalence of oral mucosal lesions in children and youths in the USA. Int J Paediatr Dent 2005; 15(2):89-97.

Shulman JD, Beach MM, Rivera-Hidalgo F. The prevalence of oral mucosal lesions in US adults: Data from the Third National Health and Nutrition Examination Survey, 1988-1994. J Am Dent Assoc 2004; 135(9):1279-86.

Kondori I, Mottin RW, Laskin DM. Accuracy of dentists in the clinical diagnosis of oral lesions. Quintessence Int 2011; 42(7):575-7.

Sarabadani J, Ghanbariha M, Khajehahmadi S, Nehighalehno M. Consistency rates of clinical and histopathologic diagnosis of oral soft tissue exophytic lesions. J Dent Res Dent Clin Dent Prospects 2009; 3(3):86-9.

Patel KJ, De Silva HL, Tong DC, Love RM. Concordance between clinical and histopathologic diagnosis of oral mucosal lesions. J Oral Maxillofac Surg 2011; 69(1):125-33.

Saghravanian N, HosseinpourJajarm H, Salehinejad J, AfzalAghaie M, Ghazi N. A 30-year comparison of clinical and histopathological diagnosis in salivary gland lesions, odontogenic cysts and tumors in Mashhad Dental School - Iran. J Mash Dent Sch 2010; 34(4):299-308.

Hashemipour M, Rad M, Mojtahedi A. A comparative study of clinical diagnosis and histological reports of oral and jaw lesions. J Dent 2009; 10(1):31-7.

Razavi SM, Ghorani N. Concordance between clinical and histopathological diagnosis of oral hard tissue lesions in Isfahan over a 24-year period. J Isfahan Dent Sch 2014; 10(5):382-90.

Chen S, Forman M, Sadow PM, August M. The diagnostic accuracy of incisional biopsy in the oral cavity. J Oral Maxillofac Surg 2016; 74(5):959-64.

Shiva A, Sobouti F. Comparative study of histopathological reports and clinical diagnosis of oral biopsies. J Mazandaran Univ Med Sci 2016; 26(144):57-64.

Tyndorf MM, Manowska B, Arkuszewski P. Usefulness of classic radiographs in the preliminary evaluation of mandibular radiolucencies. Wiad Lek 2008; 61(10-12):258-62. [Article in Polish]

Jajarm HH, Mohtasham N. A comparative study on the clinical diagnosis and pathology report of patients undergone biopsy at department of Oral Medicine of Mashhad Dental School from 2002 until 2004. J Mash Dent Sch 2006; 30:47-54.

Ashkavandi ZJ, Rezvani G, Mardanifard H. Evaluation of the agreement rate of clinical and histopathologic diagnosis in patients referring to oral pathology department of Shiraz Dental School, 2001-2006. J Dent 2010; 11(2):161-8.