Bioethics in Reusing of Biomedical Waste in Regenerative Dentistry

Marco Tatullo

Abstract


Stem cell-based therapies are the most promising breakthrough in almost all the fields of medicine. Despite stem cells are widely investigated, scientific community is still debating if stemness is a peculiar ability of a specific cytotype or if any differentiated cell may adopt stem-cell-like properties, according to an organ’s needs. Resident stem cells undergo to changes in chromatin structure depending from stimulus-responsive transcriptional programs highlighting how stem cells can be induced during both embryonic development and adult tissue regeneration in several different tissues, regardless of their biological niche. Biological wastes are usually considered as matter to be discharged, but in the last years, especially after the Nobel Prize in Physiology or Medicine to Randy Schekman, the interest toward the re-use of wasted tissues has become a hot topic in biomedical research. 


Keywords


Bioethics; Dentistry; Stem Cells

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References


Muñoz-Cánoves P, Huch M. Definitions for adult stem cells debated. Nature 2018; 563(7731):328-9. https://doi.org/10.1038/d41586-018-07175-6

Ransom RC, Carter AC, Salhotra A, Leavitt T, Marecic O, Murphy MP, et al. Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration. Nature 2018; 563(7732):514-21. https://doi.org/10.1038/s41586-018-0650-9

Eisenstein M. Molecular biology: Remove, reuse, recycle. Nature 2014; 514:S2-S4. https://doi.org/10.1038/514S2a

Tatullo M. About stem cell research in dentistry: Many doubts and too many pitfalls still affect the regenerative dentistry. Int J Med Sci 2018; 15(14):1616-8. https://doi.org/10.7150/ijms.27908

Tatullo M, Codispoti B, Pacifici A, Palmieri F, Marrelli M, Pacifici L, Paduano F. Potential Use of human periapical cyst-mesenchymal stem cells (hPCy-MSCs) as a novel stem cell source for regenerative medicine applications. Front Cell Dev Biol 2017; 5:103. https://doi.org/10.3389/fcell.2017.00103

Paduano F, Marrelli M, Palmieri F, Tatullo M. CD146 expression influences periapical cyst mesenchymal stem cell properties. Stem Cell Rev 2016; 12(5):592-603. https://doi.org/10.1007/s12015-016-9674-4

Paduano F, Marrelli M, Amantea M, Rengo C, Rengo S, Goldberg M, et al. Adipose tissue as a strategic source of mesenchymal stem cells in bone regeneration: A topical review on the most promising craniomaxillofacial applications. Int J Mol Sci 2017; 18(10):2140. https://doi.org/10.3390/ijms18102140

Tatullo M, Marrelli M, Paduano F. The regenerative medicine in oral and maxillofacial surgery: The most important innovations in the clinical application of mesenchymal stem cells. Int J Med Sci 2015; 12(1):72-7. https://doi.org/10.7150/ijms.10706

Marrelli M, Paduano F, Tatullo M. Human periapical cyst-mesenchymal stem cells differentiate into neuronal cells. J Dent Res 2015; 94(6):843-52. https://doi.org/10.1177/0022034515570316

Tatullo M, Simone GM, Tarullo F, Irlandese G, Vito D, Marrelli M, et al. Antioxidant and antitumor activity of a bioactive polyphenolic fraction isolated from the brewing process. Sci Rep 2016; 6:36042. https://doi.org/10.1038/srep36042




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