@article{Bagde_Banakar_Waghmare_Bagde_Chaturvedi_Patil_2021, title={Assessment of the Relationship Between Matrix Metalloproteinase-9 Promoter Gene Polymorphism and Chronic Periodontitis}, volume={21}, url={https://revista.uepb.edu.br/PBOCI/article/view/745}, abstractNote={<p><strong>Objective: </strong>To evaluate the association of MMP-9 promoter gene polymorphism in generalized chronic periodontitis patients of an Indian population. <strong>Material and Methods:</strong> Eighty patients were selected and divided into case and control groups (n=40). Patients included were aged 15-60 years of both genders and diagnosed with chronic periodontitis. Peripheral venous blood samples were obtained, and genomic DNA was isolated by a 'salting out' method. Three possible genotypes were distinguished by three distinct banding patterns, depending on the presence or absence of the Sph I restriction site: CC as allele 1, TT as allele 2, and CT, respectively. Statistical analysis was carried out by applying the Chi-squared test and One-way ANOVA. <strong>Results:</strong> There was a significant difference in MMP-9 genotypes between Chronic periodontitis patients and healthy controls. Odds ratios for CT genotype and combination of CT and TT genotypes were 3.125 (95% confidence interval, p=0.028) and 3.667 (95% confidence interval, p=0.006) relative to subjects with CC genotype, respectively. <strong>Conclusion:</strong> The present study revealed an association of MMP-9 (-1562 C/T) gene polymorphism with generalised chronic periodontitis.</p>}, journal={Pesquisa Brasileira em Odontopediatria e ClĂ­nica Integrada}, author={Bagde, Hiroj and Banakar, Savitha and Waghmare, Alka and Bagde, Ashwini and Chaturvedi, Shailendra Singh and Patil, Santosh Rayagouda}, year={2021}, month={Nov.}, pages={e0264} }