TY - JOUR AU - Bagde, Hiroj AU - Banakar, Savitha AU - Waghmare, Alka AU - Bagde, Ashwini AU - Chaturvedi, Shailendra Singh AU - Patil, Santosh Rayagouda PY - 2021/11/16 Y2 - 2024/03/28 TI - Assessment of the Relationship Between Matrix Metalloproteinase-9 Promoter Gene Polymorphism and Chronic Periodontitis JF - Pesquisa Brasileira em Odontopediatria e ClĂ­nica Integrada JA - Pesqui Bras Odontopediatria Clin Integr VL - 21 IS - SE - DO - UR - https://revista.uepb.edu.br/PBOCI/article/view/745 SP - e0264 AB - <p><strong>Objective: </strong>To evaluate the association of MMP-9 promoter gene polymorphism in generalized chronic periodontitis patients of an Indian population. <strong>Material and Methods:</strong> Eighty patients were selected and divided into case and control groups (n=40). Patients included were aged 15-60 years of both genders and diagnosed with chronic periodontitis. Peripheral venous blood samples were obtained, and genomic DNA was isolated by a 'salting out' method. Three possible genotypes were distinguished by three distinct banding patterns, depending on the presence or absence of the Sph I restriction site: CC as allele 1, TT as allele 2, and CT, respectively. Statistical analysis was carried out by applying the Chi-squared test and One-way ANOVA. <strong>Results:</strong> There was a significant difference in MMP-9 genotypes between Chronic periodontitis patients and healthy controls. Odds ratios for CT genotype and combination of CT and TT genotypes were 3.125 (95% confidence interval, p=0.028) and 3.667 (95% confidence interval, p=0.006) relative to subjects with CC genotype, respectively. <strong>Conclusion:</strong> The present study revealed an association of MMP-9 (-1562 C/T) gene polymorphism with generalised chronic periodontitis.</p> ER -