Presence of Type 1 Collagen Alpha-2 (COL1A2) (rs42524) Gene Polymorphism and Scar Tissue Formation in Different Areas of Head and Neck

David Solomonovich  Avetikov; Olga Petrivna  Buchanhenko; Oksana Anatoliivna  Shlykova; Olga Vitaliivna  Izmajlova; Kateryna Petrivna  Lokes; Oksana Vasylivna  Klitynska; Ludmila Eduardivna  Vesnina; Igor Petrovich  Kajdashev

Authors

David Solomonovich Avetikov
Olga Petrivna Buchanhenko
Oksana Anatoliivna Shlykova
Olga Vitaliivna Izmajlova
Kateryna Petrivna Lokes
Oksana Vasylivna Klitynska
Ludmila Eduardivna Vesnina
Igor Petrovich Kajdashev

Keywords:

Pathology, Oral, Cicatrix, Collagen Type I, Polymorphism, Genetic

Abstract

Objective: To determine the effect type I collagen gene polymorphism alpha-2 (COL1A2) (rs42524) on the formation of scar tissue that is localized in the head and neck areas. Material and Methods: Sixty patients with scars in different areas of the head and neck were examined. The patients were divided into four subgroups, according to the types of scarring: G I: 15 patients with normotrophic scars; G ІІ: 15 patients with atrophic scars; G ІІІ: 15 patients with hypertrophic scars; and G IV: 15 patients with keloid scars. The age of patients ranged from 17 to 54 years. The single-nucleotide polymorphic site of the COL1A2 (rs42524) gene was detected by a polymerase chain reaction and subsequent analysis of restriction fragment lengths. Pearson's chi-squared test with Yates’s correction and Fischer's exact test were used. Results: There were no significant changes between the control and basic groups (p=0.83) at analyzing the frequencies of G and C alleles. For the G allele, the calculation of odds ratio between the basic and control groups was 0.93 at 95% confidence interval (CI) (0.50-1.75), for the C allele – OR was 1.07 at 95% CI (0.57- 2.01). Conclusion: Our studies may indirectly indicate the activation of the skin’s protective reaction to physiological scarring and dosed scar formation in different areas of the head and neck.

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