Effect of Different Preparations of Fluoride Gel on Salivary pH of Albino Rats
Keywords:
Acidulated Phosphate Fluoride, Dental Caries, Saliva, Salivary Glands, Sodium FluorideAbstract
Objective: To evaluate the effect of different preparations of fluoride gels on the salivary pH of albino rats. Material and Methods: This experimental study consisted of 40 Albino rats randomly divided into four equal groups. Group A was the control group and received no intervention. Experimental group B received a topical application of 0.2% sodium fluoride gel. Experimental group C received topical application of stannous fluoride gel 0.4%. Experimental group D received topical application of APF gel (1.23% acidulated phosphate fluoride gel). The different preparations of the gels were applied once daily for 4 minutes on the occlusal surface of the right maxillary molars for 14 days. Salivary pH values were recorded immediately after the application of gels with the help of pH paper on day 1 and day 14. Results: There was a significant difference in the pH level of groups B, C and D after 14 days of fluoride application (p < 0.05). The non-parametric Kruskal Wallis test was applied for the comparison between the groups. Conclusion: This study concluded that all the fluoride gels after administration caused the acidic pH of saliva with the most acidic effect produced by APF gel.
References
Bansal A, Ingle NA, Kaur N, Ingle E. Recent advancements in fluoride: A systematic review. J Int Soc Prev Community Dent 2015; 5(5):341-6. https://doi.org/10.4103/2231-0762.165927
Yin IX, Yu OY, Zhao IS, Mei ML, Li QL, Tang J, et al. Inhibition of dentine caries using fluoride solution with silver nanoparticles: An in vitro study. J Dent 2020; 103:103512. https://doi.org/10.1016/j.jdent.2020.103512
Uma E, Theng KS, Yi LLH, Yun LH, Varghese E, Soe HHK. Comparison of salivary pH changes after consumption of two sweetened Malaysian local drinks among individuals with low caries experience: a pilot study. Malays J Med Sci 2018; 25(4):100-11. https://doi.org/10.21315/mjms2018.25.4.10
Kao Y-H, Igarashi N, Abduweli Uyghurturk D, Li Z, Zhang Y, Ohshima H, et al. Fluoride alters signaling pathways associated with the initiation of dentin mineralization in enamel fluorosis susceptible mice. Biol Trace Elem Res 2021; 199(8):3021-34. https://doi.org/10.1007/s12011-020-02434-y
Duangthip D, Chen KJ, Gao SS, Lo ECM, Chu CH. Managing early childhood caries with atraumatic restorative treatment and topical silver and fluoride agents. Int J Environ Res Public Health 2017; 14(10):1204. https://doi.org/10.3390/ijerph14101204
Lussi A, Buzalaf MAR, Duangthip D, Anttonen V, Ganss C, João-Souza SH, et al. The use of fluoride for the prevention of dental erosion and erosive tooth wear in children and adolescents. Eur Arch Paediatr Dent 2019; 20(6):517-27. https://doi.org/10.1007/s40368-019-00420-0
Baik A, Alamoudi N, El-Housseiny A, Altuwirqi A. Fluoride varnishes for preventing occlusal dental caries: a review. Dent J 2021; 9(6):64. https://doi.org/10.3390/dj9060064
Slayton RL, Urquhart O, Araujo MW, Fontana M, Guzmán-Armstrong S, Nascimento MM, et al. Evidence-based clinical practice guideline on nonrestorative treatments for carious lesions: a report from the American Dental Association. J Am Dent Assoc 2018; 149(10):837-49. e19. https://doi.org/10.1016/j.adaj.2018.07.002
Warreth A, Abuhijleh E, Almaghribi MA, Mahwal G, Ashawish A. Tooth surface loss: a review of literature. Saudi Dent J 2020; 32(2):53-60. https://doi.org/10.1016/j.sdentj.2019.09.004
Fiorillo L, Cervino G, Herford AS, Laino L, Cicciù M. Stannous fluoride effects on enamel: a systematic review. Biomimetics 2020; 5(3):41. https://doi.org/10.3390/biomimetics5030041
Sudhanthar S, Lapinski J, Turner J, Gold J, Sigal Y, Thakur K, et al. Improving oral health through dental fluoride varnish application in a primary care paediatric practice. BMJ Open Quality 2019; 8(2):e000589. https://doi.org/10.1136/bmjoq-2018-000589
Bel’skaya LV, Kosenok VK, Sarf EA. Chronophysiological features of the normal mineral composition of human saliva. Arch Oral Biol 2017; 82:286-92. https://doi.org/10.1016/j.archoralbio.2017.06.024
Lan X, Chan JYK, Pu JJ, Qiao W, Pang S, Yang W-f, et al. Saliva electrolyte analysis and xerostomia-related quality of life in nasopharyngeal carcinoma patients following intensity-modulated radiation therapy. Radiother Oncol 2020; 150:97-103. https://doi.org/10.1016/j.radonc.2020.06.016
Raghavan R, Shajahan P, Gibi M. An insight into the science behind saliva and its crucial role in oral health. J Dent Panacea 2021; 3(2):52-7. https://doi.org/10.18231/j.jdp.2021.013
Ngamchuea K, Chaisiwamongkhol K, Batchelor-McAuley C, Compton RG. Chemical analysis in saliva and the search for salivary biomarkers - a tutorial review. The Analyst 2017; 143(1):81-99. https://doi.org/10.1039/c7an01571b
Kim B, Lee SS, Yoo TH, Kim JM. Viscoelastic particle focusing in human biofluids. Electrophoresis 2021; 42(21-22):2238-45. https://doi.org/10.1002/elps.202000280
Devarajan H, Somasundaram S. Salivary proteins and its effects on dental caries – a review. Drug Invent Today 2019; 11(6):1406-11.
Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, et al. The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. Br J Pharmacol 2020; 40(9):1769-77. https://doi.org/10.1177/0271678X20943823
Chen X, Xing H, Zhou Z, Hao Y, Zhang X, Qi F, et al. Nanozymes go oral: nanocatalytic medicine facilitates dental health. J Mater Chem 2021; 9(6):1491-502. https://doi.org/10.1039/D0TB02763D
Bajraktarova-Valjakova E, Grozdanov A, Guguvcevski L, Korunoska-Stevkovska V, Kapusevska B, et al. Acid etching as surface treatment method for luting of glass-ceramic restorations, part 1: acids, application protocol and etching effectiveness. Open Access Maced J Med Sci 2018; 6(3):568-73. https://doi.org/10.3889/oamjms.2018.147
Su H, Yang R, Deng Q, Qian W, Yu J. Deciduous dental caries status and associated risk factors among preschool children in Xuhui District of Shanghai, China. BMC Oral Health 2018; 18(1):111. https://doi.org/10.1186/s12903-018-0565-8
Shakeel S, Majid H, Ashraf M, Ilyas MS. Histological effect of sodium fluoride and stannous fluoride gels on buccal mucosa of albino rat. Pak Postgrad Med J 2019; 30(01):12-6.
Johannsen A, Emilson CG, Johannsen G, Konradsson K, Lingström P, Ramberg P. Effects of stabilized stannous fluoride dentifrice on dental calculus, dental plaque, gingivitis, halitosis and stain: a systematic review. Heliyon 2019; 5(12):e02850. https://doi.org/10.1016/j.heliyon.2019.e02850
Gupta A, Sharda S, Nishant, Shafiq N, Kumar A, Goyal A. Topical fluoride-antibacterial agent combined therapy versus topical fluoride monotherapy in preventing dental caries: a systematic review and meta-analysis. Eur Arch Paediatr Dent 2020; 21(6):629-46. https://doi.org/10.1007/s40368-020-00561-7
Urquhart O, Tampi MP, Pilcher L, Slayton RL, Araujo MWB, Fontana M, et al. Nonrestorative treatments for caries: systematic review and network meta-analysis. J Dent Res 2019; 98(1):14-26. https://doi.org/10.1177/0022034518800014
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