Human Oral Microbiome and Systemic Diseases: What Stage are We at?


  • Pablo Alejandro Millones-Gómez


Mouth, Microbiota, Periodontal Diseases


The oral cavity is a dynamic ecosystem comprising an array of microbial communities, including many pathogenic or opportunistic species. Recent studies have also demonstrated the role of periodontal disease as a risk factor or enhancer of distant systemic pathologies such as Alzheimer's disease and colorectal cancer with bacterial periodontopathogens such as Porphyromonas gingivalis and Fusobacterium nucleatum, respectively. Since the publication of the results of the human microbiome project, it was shown that microorganisms do not have unique niches and their presence in various locations does not necessarily generate disease. We should emphasize that we are just beginning to know the characteristics of microbiomes, their variability influenced by various factors, and their interaction with the host.


Bourgeois D, Gonçalves LS, Lima-Junior JDC, Carrouel F. Editorial: The Oral Microbiome is a Key Factor in Oral and Systemic Health. Front Microbiol 2022; 13:855668.

Kapila YL. Oral health's inextricable connection to systemic health: Special populations bring to bear multimodal relationships and factors connecting periodontal disease to systemic diseases and conditions. Periodontol 2000 2021; 87(1):11-6.

Reitano E, de'Angelis N, Gavriilidis P, Gaiani F, Memeo R, Inchingolo R, et al. Oral bacterial microbiota in digestive cancer patients: a systematic review. Microorganisms 2021; 9(12):2585.

Gomaa EZ. Human gut microbiota/microbiome in health and diseases: a review. Antonie van Leeuwenhoek 2020; 113(12):2019-2040.

Dibello V, Lozupone M, Manfredini D, Dibello A, Zupo R, Sardone R, et al. Oral frailty and neurodegeneration in Alzheimer's disease. Neural Regen Res 2021; 16(11):2149-53.

Integrative HMP (iHMP) Research Network Consortium. The Integrative Human Microbiome Project. Nature 2019; 569(7758):641-8.




How to Cite

Millones-Gómez, P. A. (2022). Human Oral Microbiome and Systemic Diseases: What Stage are We at?. Pesquisa Brasileira Em Odontopediatria E Clínica Integrada, 22, e220050. Retrieved from



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