Research Trends on Preventive and Therapeutic Use of TIF4 for Dental Caries and Erosion

Authors

  • Ana Beatriz Chevitarese
  • Karla Lorene de França Leite
  • Guido Artemio Marañón-Vásquez
  • Danielle Masterson
  • José M. Vicente-Gomila
  • Andréa Fonseca Gonçalves
  • Matheus Pitton
  • Lucianne Cople Maia

Keywords:

Dental Caries, Fluorides, Tooth Erosion

Abstract

Objective: To evaluate TIF4 preventive and therapeutic use in caries and erosive lesions. Material and Methods: Searches were performed in six databases. Studies evaluating TiF4 use in vitro, in situ, and in vivo in caries and erosive lesions were included and imported into VantagePoint™ (VP). Data about publication year, authors, country, journal, study design, outcomes, TIF4 vehicles, application and intervention time, cariogenic challenge, erosive cycles, effects (positive/ negative /null) and approach (preventive/therapeutic) were analyzed through VP and Excel. Results: 93 published studies were included and an increase in publications was observed between 2010 and 2021. Forty-three authors published three or more articles, of which 67.4% were developed in Brazil and published in Caries Research (22.6%). 69.9% were in vitro studies with erosion assays (59.1%) and with preventive approaches (67.4%). The principal vehicle was a solution (69.9%) with a 1-min single application (58.0%) and with an intervention time of 5-7 days (22.6%). The principal cariogenic challenge in vitro was pH cycling (11.8%); in situ was sucrose + biofilm (6.2%); and in vivo, biofilm (6.2%). The most used erosive cycle was 4× per day in in vitro studies (20.4%) and 1× in vivo (2.1%). A positive effect was observed in prevention (41.9%) and treatment (24.7%) studies. Conclusion: TIF4 has shown a positive effect in prevention and therapeutic treatments for dental caries and erosion.

References

Simón-soro A, Mira A. Solving the etiology of dental caries. Trends in Microbiol 2015; 23(2):76-82. https://doi.org/10.1016/j.tim.2014.10.010

Kreulen CM, Van T Spijker A, Rodriguez JM, Bronkhorst EM, Creugers NH, Bartlett DW. Systematic review of the prevalence of tooth wear in children and adolescents. Caries Res 2010; 44(2):151-9. https://doi.org/10.1159/000308567

Buzalaf MA, Hannas AR, Kato MT. Saliva and dental erosion. J Appl Oral Sci 2012; 20(5):493-502. https://doi.org/10.1590/s1678-77572012000500001

Tjäderhane L, Buzalaf MA, Carrilho M, Chaussain C: Matrix metalloproteinases and other matrix proteinases in relation to cariology: the era of ‘dentin degradomics’. Caries Res 2015; 49(3):193-208. https://doi.org/10.1159/000363582

Ijaz S, Croucher RE, Marinho VCC. Systematic reviews of topical fluorides for dental caries: a review of reporting practice. Caries Res 2010; 44(6):579-92. https://doi.org/10.1159/000322132

Magalhães AC, Wiegand A, Rios D, Buzalaf MAR, Lussi A. Fluoride in dental erosion. Monogr Oral Sci 2011; 22:158-170. https://doi.org/10.1159/000325167

Shrestha BM, Mundorff SA, Bibby BG. Enamel Dissolution I: Effects of various agents and titanium tetrafluoride. J Dent Res 1972; 51(6):1561-6. https://doi.org/10.1177/00220345720510060901

Wefel JS, Harless JD. The effect of several topical fluoride agents on artificial lesion formation. J Dent Res 1982; 61(10):1169-71. https://doi.org/10.1177/00220345820610101201

Kazemi RB, Sen BH, Spangberg LS. Permeability changes of dentine treated with titanium tetrafluoride. J Dent 1999; 27(7):531-8. https://doi.org/10.1016/s0300-5712(99)00029-9

Kazemi RB, Sen BH, Spangberg LS. Morphologic effects on L929 fibroblasts of titanium tetrafluoride application. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998; 86(3):341-6. https://doi.org/10.1016/s1079-2104(98)90183-4

Alexandria AK, Nassur C, Nóbrega CBC, Valença AMG, Rosalen PL, Maia LC. In situ effect of titanium tetrafluoride varnish on enamel demineralization. Braz Oral Res 2017; 31:e86. https://doi.org/10.1590/1807-3107bor-2017.vol31.0086

Comar LP, Gomes MF, Ito N, Salomão PA, Grizzo LT, Magalhães AC. Effect of NaF, SnF2, and TiF4 Toothpastes on Bovine Enamel and Dentin Erosion-Abrasion In Vitro. Int J Dent 2012; 2012:134350. https://doi.org/10.1155/2012/134350

Mantilla TF, Turssi CP, Ramos-Oliveira TM, Silva CVD, Suzuki LC, Freitas PM. The In Situ Effect of Titanium Tetrafluoride Gel on Erosion/Abrasion Progression in Human Dentin. Braz Dent J 2017; 28(3):337-345. https://doi.org/10.1590/0103-6440201601247

Skartveit L, Selvig KA, Myklebust S, Tveit AB. Effect of TiF4 solutions on bacterial growth in vitro and on tooth surfaces. Acta Odontol Scand 1990; 48(3):169-174. https://doi.org/10.3109/00016359009005872

Wiegand A, Hiestand B, Sener B, Magalhaes AC, Roos M, Attin T. Effect of TiF4, ZrF4, HfF4 and AmF on erosion and erosion/abrasion of enamel and dentin in situ. Arch Oral Biol 2010; 55(3):223-8.. https://doi.org/10.1016/j.archoralbio.2009.11.007

Pomarico L, Villardi M, Maia LC. In vivo effect of titanium tetrafluoride and sodium monofluorophosphate dentifrice on remineralization: A preliminary split-mouth clinical trial. Gen Dent 2012; 60(4):e249-54.

Elsaka SE, Elnaghy AM. Bonding durability of titanium tetrafluoride treated glass fiber post with resin cement. Dent Mater J 2019; 38(2):189-195. https://doi.org/10.4012/dmj.2018-054

Comar LP, Wiegand A, Moron BM, Rios D, Buzalaf MAR, Buchalla W, et al. In situ effect of sodium fluoride or titanium tetrafluoride varnish and solution on carious demineralization of enamel. Eur J Oral Sci 2012; 120(4):342-8. https://doi.org/10.1111/j.1600-0722.2012.00968.x

Mantilla TF, Freitas PM. Titanium Tetrafluoride (TiF4) in the Treatment of Dental Erosion. J Health Sci 2017; 19(4):236-40.

Souza BM, Santos DMS, Braga AS, Santos NMD, Rios D, Buzalaf MAR, et al. Effect of a titanium tetrafluoride varnish in the prevention and treatment of carious lesions in the permanent teeth of children living in a fluoridated region: protocol for a randomized controlled trial. JMIR Res Protoc 2018; 7(1):e26. https://doi.org/10.2196/resprot.9376

Magalhães AC, Levy FM, Rios D, Buzalaf MAR. Effect of a single application of TiF4 and NaF varnishes and solutions on dentin erosion in vitro. J Dent 2010; 38(2):153-7. https://doi.org/10.1016/j.jdent.2009.09.015

Magalhães AC, Romanelli AC, Rios D, Comar LP, Navarro RS, Grizzo LT, et al. Effect of a single application of TiF4 and NaF varnishes and solutions combined with Nd:YAG laser irradiation on enamel erosion in vitro. Photomed Laser Surg 2012; 29(8):537–544. https://doi.org/10.1089/pho.2010.2886

Magalhães AC, Levy FM, Rizzante FA, Rios D, Buzalaf MAR. Effect of NaF and TiF4varnish and solution on bovine dentin erosion plus abrasion in vitro. Acta Odontol Scand 2011; 70(2):160-4. https://doi.org/10.3109/00016357.2011.600711

Magalhães AC, Dos Santos MG, Comar LP, Buzalaf MAR, Ganss C, Schlueter N. Effect of a single application of TiF4 varnish versus daily use of a low-concentrated TiF4/NaF solution on tooth erosion prevention in vitro. Caries Res 2016; 50(5):462-70. https://doi.org/10.1159/000448146

Comar LP, Souza BM, Grizzo LT, Buzalaf MAR, Magalhães AC. Evaluation of fluoride release from experimental TiF4 and NaF varnishes in vitro. J Appl Oral Sci 2014; 22(2):138-43. https://doi.org/10.1590/1678-775720130574

Comar LP, Cardoso CAB, Charone S, Grizzo LT, Buzalaf MAR, Magalhães AC. TiF4 and NaF varnishes as anti-erosive agents on enamel and dentin erosion progression in vitro. J Appl Oral Sci 2015; 23(1):14-8. https://doi.org/10.1590/1678-775720140124

Comar LP, Souza BM, Al-Ahj LP, Martins J, Grizzo LT, Piasentim IS, et al. Mechanism of action of TiF4 on dental enamel surface: SEM/EDX, KOH-soluble F, and x-ray diffraction analysis. Caries Res 2017; 51(6):554-67. https://doi.org/10.1159/000479038

Comar LP, Souza BM, Martins J, Santos MG, Buzalaf MAR, Magalhães AC. Response of carious enamel to TiF 4 varnish treatment under diverse cariogenic activities in situ. J Dent 2017; 63:81-4. https://doi.org/10.1016/j.jdent.2017.05.023

Cross DI, Thomson S, Sibclair A. Research in Brazil: A report for CAPES by Clarivate Analytics. Clarivate Analytics, 2018.

Souza BM, Lima LLM, Comar LP, Buzalaf MAR, Magalhães AC. Effect of experimental mouthrinses containing the combination of NaF and TiF4 on enamel erosive wear in vitro. Arch Oral Biol 2014; 59(6):621-4. https://doi.org/10.1016/j.archoralbio.2014.03.008

Santos DMS, Pires JG, Silva AB, Salomão PMA, Buzalaf MAR, Magalhães AC. Protective effect of 4% titanium tetrafluoride varnish on dentin demineralization using a microcosm biofilm model. Caries Res 2019; 53(5):576-83. https://doi.org/10.1159/000499317

Alcântara PCC, Alexandria AK, Souza IPR, Maia LC. In Situ effect of titanium tetrafluoride and sodium fluoride on artificially decayed human enamel. Braz Dent J 2014; 25(1):28–32. https://doi.org/10.1590/0103-6440201302329

Büyükyilmaz T, Tangugsorn V, Øgaard B, Arends J, Ruben J, Rølla G. The effect of titanium tetrafluoride (TiF4) application around orthodontic brackets. Am J Orthod Dentofacial Orthop 1994; 105(3):293-6. https://doi.org/10.1016/s0889-5406(94)70124-5

Buyukyilmaz T, Ogaard B, Rolla G. The resistance of titanium tetrafluoride treated human enamel to strong hydrochloric acid. Eur J Oral Sci 1997; 105(5 Pt 2):473-7. https://doi.org/10.1111/j.1600-0722.1997.tb00233.x

Morais AP, Souza IPR, Chevitarese O. An in situ study of human enamel after titanium tetrafluoride application. Pesq Odont Bras 2000; 14(2):137-43. https://doi.org/10.1590/S1517-74912000000200008

Castro RDL, Chevitarese O, Souza IPR. Action of titanium tetrafluoride on occlusion human enamel in situ. Fluorides 2003; 36(4):252-62.

Chevitarese AB, Chevitarese O, Chevitarese LM, Dutra PB. Titanium penetration in human enamel after TiF4 application. J Clin Pediatr Dent 2004; 28(3):253-6. https://doi.org/10.17796/jcpd.28.3.jn86252876j75053

Magalhães AC, Comar LP, Rios D, Delbem ACB, Buzalaf MAR. Effect of a 4% titanium tetrafluoride (TiF4) varnish on demineralisation and remineralisation of bovine enamel in vitro. J Dent 2008; 36(2):158-62. https://doi.org/10.1016/j.jdent.2007.12.001

Reed AJ, Bibby BG. Preliminary report on effect of topical applications of titanium tetrafluoride on dental caries. J Dent Res 1976; 55(3):357-8. https://doi.org/10.1177/00220345760550031101

Hjortsjo C, Jonski G, Thrane PS, Saxegaard E, Young A. The effects of acidic fluoride solutions on early enamel erosion in vivo. Caries Res 2009; 43(2):126-31. https://doi.org/10.1159/000209345

Polli JE. In vitro studies are sometimes better than conventional human pharmacokinetic in vivo studies in assessing bioequivalence of immediate-release solid oral dosage forms AAPS J 2008; 10(2):289-99. https://doi.org/10.1208/s12248-008-9027-6

Magalhães AC, Kato MT, Rios D, Wiegand A, Attin T, Buzalaf MAR. The effect of an experimental 4% Tif4 varnish compared to NaF varnishes and 4% TiF4 solution on dental erosion in vitro. Caries Res 2008; 42(4):269-74. https://doi.org/10.1159/000135672

Exterkate RA, Ten Cate JM. Effects of a new titanium fluoride derivative on enamel de- and remineralization. Eur J Oral Sci 2007; 115(2):143-7. https://doi.org/10.1111/j.1600-0722.2007.00431.x

Stenhagen KR, Hove LH, Holme B, Tveit AB. The effect of daily fluoride mouth rinsing on enamel erosive/abrasive wear in situ. Caries Res 2013; 47:2-8. https://doi.org/10.1159/000342619

Levy FM, Rios D, Buzalaf MAR, Magalhaes AC. Efficacy of TiF4 and NaF varnish and solution: a randomized in situ study on enamel erosive–abrasive wear. Clin Oral Invest 2014; 18:1097-1102. https://doi.org/10.1007/s00784-013-1096-y

Lepri TP, Colucci V, Turssi CP, Corona SAM. In situ investigation of the effect of TiF4 and CO2 laser irradiation on the permeability of eroded enamel. Arch Oral Biol 2015; 60(6):941-7. https://doi.org/10.1016/j.archoralbio.2015.02.001

Alexandria AK, Nassur C, Nóbrega CBC, Branco-de-Almeida, LS, Santos KRN, Vieira, AR, et al. Effect of TiF4 varnish on microbiological changes and caries prevention: in situ and in vivo models. Clin Oral Investig 2019; 23(6):2583-91. https://doi.org/10.1007/s00784-018-2681-x

Alcantara PCC, Alexandria AK, Souza IPR, Maia LC. Energy dispersive x-ray spectroscopy evaluation of demineralized human enamel after titanium tetrafluoride application. J Clin Pediatr Dent 2015; 39(2):124-7. https://doi.org/10.17796/jcpd.39.2.778531q560886x5r

Vieira A, Lugtenborg M, Ruben JL, Huysmans MC. Brushing abrasion of eroded bovine enamel pretreated with topical fluorides. Caries Res 2006; 40(3):224-30. https://doi.org/10.1159/000092230

Pedro RL, Pomarico L, Villardi M, Maia LC. Adverse effects associated with the clinical use of 4% TiF(4) on teeth enamel: case report. Compend Contin Educ Dent 2011, 32(4):66-8.

Schlueter N, Ganss C, Mueller U, Klimek J. Effect of titanium tetrafluoride and sodium fluoride on erosion progression in enamel and dentine in vitro. Caries Res 2007; 41(2):141-5. https://doi.org/10.1159/000098048

Mosquim V, Rodrigues LPS, Martines BS, Magalhães AC. Can TiF4 varnish or TiF4/NaF solution stain eroded and sound enamel? J Dent 2019; 85:11-7. https://doi.org/10.1016/j.jdent.2019.04.006

Huggins CB, Froehlich JP. High concentration of injected titanium dioxide in abdominal lymph nodes. J Exp Med 1966; 124(6):1099-106. https://doi.org/10.1084/jem.124.6.1099

Shrestha B, Olsen T. Effects of systemically administered titanium tetrafluoride on rat caries. J Dent Res 1980; 59:509.

Shrestha BM. Effect of systemic titanium tetrafluoride (TiF4) on fluoride uptake by developing rat enamel. Caries Res 1983; 17(3):264-6. https://doi.org/10.1159/000260676

Vieira TI, Nassur C, Alexandria AK, Pomarico L, Sousa VP, Cabral LM, et al. Effect of the inclusion nanocomplex formed of titanium tetrafluoride and beta-cyclodextrin on enamel remineralization. J Pharm Bioallied Sci 2017; 9(3):201-7. https://doi.org/10.4103/jpbs.JPBS_161_16

Dutra PB. Formação dos complexos de titânio – um estudo em HCl 3 a 6M. Rio de Janeiro: UFRJ, 1988. 83 p. Thesis (Master in Science - Instituto de Química). [In Portuguese].

Morais AP, Bittencourt L, Chevitarese LM, Vaitsman DS, Souza IPR, Chevitarese O. Evaluation of bonding enamel/composite with fresh an older TiF4 solution. J Dent Res 1998; 77:816.

Castro, RL, Souza IPR, Dutra PB, Vaitsman DS. Estudo da hidrólise de soluções de tetrafluoreto de titânio através da espectrofotometria. Anais do 11º Encontro de Química Analítica, Campinas, 2001. abst. EM-24. [In Portuguese].

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Published

2023-01-24

How to Cite

Chevitarese, A. B., Leite, K. L. de F., Marañón-Vásquez, G. A., Masterson, D., Vicente-Gomila, J. M., Gonçalves, A. F., Pitton, M., & Maia, L. C. (2023). Research Trends on Preventive and Therapeutic Use of TIF4 for Dental Caries and Erosion. Pesquisa Brasileira Em Odontopediatria E Clínica Integrada, 22, e210195. Retrieved from https://revista.uepb.edu.br/PBOCI/article/view/1673

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