Donor Site Morbidity of Nonvascularized Bone Graft: A Systematic Review
Keywords:
Mandibular Reconstruction, Morbidity, Bone Transplantation, IliumAbstract
Objective: To evaluate the donor site morbidity of iliac and fibular nonvascularized bone graft after mandibular resection. Material and Methods:This study was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) in PubMed, Proquest, Science Direct, and Ebsco. A total of 12 studies met the criteria of studies in humans using iliac and fibular nonvascularized bone grafts in mandibular reconstruction after mandibular resection. Results: A greater proportion of patients received iliac nonvascularized bone graft (88.9%) than fibular nonvascularized bone graft (11.1%). Of the 385 cases of iliac bone graft, 153 cases (40%) experienced complications at the iliac donor site, whereas in 48 cases of fibular bone graft, two (4%) experienced complications at the donor site. Hemorrhage, bone fracture, infection requiring debridement, and hematoma were the major complications. Conclusion: The morbidity rate of the nonvascularized bone graft donor site of the fibula (4%) tended to be lower than that of the ilium (40%). Patient age and defect size were not significantly correlated with the occurrence of morbidity donor sites in either the ilium or fibula.
References
Silva L, Macedo R, Serpa M, Sobral A, Souza L. Global frequency of benign and malignant odontogenic tumors according to the 2005 WHO classification. J Oral Diag 2017; 2:1-8. https://doi.org/10.5935/2525-5711.20170044
Pogrel M, Kahnberg K, Andersson L. Essentials of Oral and Maxillofacial Surgery. Chichester, United Kingdom: John Wiley & Sons; 2014.
Bonanthaya K, Panneerselvam E, Manuel S, Kumar V, Rai A. Oral and Maxillofacial Surgery for the Clinician. Singapore: Springer; 2021.
Osborn TM, Helal D, Mehra P. Iliac crest bone grafting for mandibular reconstruction: 10-year experience outcomes. J Oral Biol Craniofac Res 2018; 8(1):25-9. https://doi.org/10.1016/j.jobcr.2017.12.001
Anand M, Panwar S. Commonly Utilized Non Vascularised Bone Grafts in Maxillofacial Reconstruction. In: Sun H. Surgical Management of Head and Neck Pathologies [Internet]. London: IntechOpen; 2021. https://doi.org/10.5772/intechopen.96983
Ahmed W, Adil Asim M, Ehsan A, Abbas Q. Non-vascularized autogenous bone grafts for reconstruction of maxillofacial osseous defects. J Coll Phys Surg Pak 2018; 28(1):17-21. https://doi.org/10.29271/jcpsp.2018.01.17
Oryan A, Alidadi S, Moshiri A, Maffulli N. Bone regenerative medicine: classic options, novel strategies, and future directions. J Orthop Surg Res 2014; 9(1):18. https://doi.org/10.1186/1749-799X-9-18
Agrawal A, Mehrotra D, Mohammad S, Singh RK, Kumar S, Pal US. Randomized control trial of non-vascularized fibular and iliac crest graft for mandibular reconstruction. J Oral Biol Craniofac Res 2012; 2(2):90-6. https://doi.org/10.1016/j.jobcr.2012.05.002
Rana M, Warraich R, Kokemüller H, Lemound J, Essig H, Tavassol F, et al. Reconstruction of mandibular defects—clinical retrospective research over a 10-year period -. Head Neck Oncol 2011; 3(1):23. https://doi.org/10.1186/1758-3284-3-23
Puricelli E, Chem RC. Thirty-eight-year follow-up of the first patient of mandibular reconstruction with free vascularized fibula flap. Head Face Med 2021; 17(1):46. https://doi.org/10.1186/s13005-021-00293-z
Sarukawa S, Noguchi T, Oh-Iwa I, Sunaga A, Uda H, Kusama M, et al. Bare bone graft with vascularised iliac crest for mandibular reconstruction. J Craniomaxillofac Surg 2012; 40(1):61-6. https://doi.org/10.1016/j.jcms.2011.01.017
Pang KM, Choi SW, Byun SH, Lee JY, Jung HJ, Lim KY, et al. Mandibular condylar-ramal reconstruction using vascularised costochondral graft based on the serratus anterior composite flap. J Craniomaxillofac Surg 2015; 43(7):1184-93. https://doi.org/10.1016/j.jcms.2015.04.014
Caldroney S, Ghazali N, Dyalram D, Lubek JE. Surgical resection and vascularized bone reconstruction in advanced stage medication-related osteonecrosis of the jaw. Int J Oral Maxillofac Surg 2017; 46(7):871-6. https://doi.org/10.1016/j.ijom.2017.01.023
Feuvrier D, Sagawa Y, Béliard S, Pauchot J, Decavel P. Long-term donor-site morbidity after vascularized free fibula flap harvesting: clinical and gait analysis. J Plast Reconstr Aesthet Surg 2016; 69(2):262-9. https://doi.org/10.1016/j.bjps.2015.10.007
Hadouiri N, Feuvrier D, Pauchot J, Decavel P, Sagawa Y. Donor site morbidity after vascularized fibula free flap: gait analysis during prolonged walk conditions. Int J Oral Maxillofac Surg 2018; 47(3):309-15. https://doi.org/10.1016/j.ijom.2017.10.006
Rendenbach C, Kohlmeier C, Suling A, Assaf AT, Catala-Lehnen P, Amling M, et al. Prospective biomechanical analysis of donor-site morbidity after fibula free flap. J Craniomaxillofac Surg 2016 ;44(2):155-9. https://doi.org/10.1016/j.jcms.2015.10.027
Hutton B, Salanti G, Caldwell DM, Chaimani A, Schmid CH, Cameron C, et al. The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med 2015; 162(11):777-84. https://doi.org/10.7326/M14-2385
Gadre PK, Ramanojam S, Patankar A, Gadre KS. Nonvascularized bone grafting for mandibular reconstruction: myth or reality? J Craniofac Surg 2011; 22(5):1727-35. https://doi.org/10.1097/SCS.0b013e31822e633b
ObimakindOkoje VN, Obimakinde OS, Arotiba JT, Fasola AO, Ogunlade SO, Obiechina AE. Mandibular defect reconstruction with nonvascularized iliac crest bone graft. Niger J Clin Pract 2012; 15(2):224-7. https://doi.org/10.4103/1119-3077.97334
Bai XF, Wushou A, Zheng J, Li G. An alternative approach for mandible reconstruction. J Craniofac Surg 2013; 24(2):e195-e198. https://doi.org/10.1097/SCS.0b013e3182802269
Magesh DP, Kumaravelu C, Maheshwari GU. Efficacy of PRP in the reconstruction of mandibular segmental defects using iliac bone grafts. J Maxillofac Oral Surg 2013; 12(2):160-7. https://doi.org/10.1007/s12663-012-0418-y
Scheerlinck LM, Muradin MS, van der Bilt A, Meijer GJ, Koole R, Van Cann EM. Donor site complications in bone grafting: comparison of iliac crest, calvarial, and mandibular ramus bone. Int J Oral Maxillofac Implants 2013; 28(1):222-7. https://doi.org/10.11607/jomi.2603
Akbay E, Aydogan F. Reconstruction of isolated mandibular bone defects with non-vascularized corticocancellous bone autograft and graft viability. Auris Nasus Larynx 2014; 41(1):56-62. https://doi.org/10.1016/j.anl.2013.07.002
Ndukwe KC, Aregbesola SB, Ikem IC, Ugboko VI, Adebiyi KE, Fatusi OA, et al. Reconstruction of mandibular defects using nonvascularized autogenous bone graft in Nigerians. Niger J Surg 2014; 20(2):87-91. https://doi.org/10.4103/1117-6806.137309
Akinbami BO, Akadiri OA. Reconstruction of the mandible following benign tumor ablations: an audit of 20 cases. J Oral Maxillofac Surg Med Pathol 2015; 27(5):650-5. https://doi.org/10.1016/j.ajoms.2015.01.009
Marechek A, AlShare A, Pack S, Demko C, Quereshy FA, Baur D. Nonvascularized bone grafts for reconstruction of segmental mandibular defects: is length of graft a factor of success? J Oral Maxillofac Surg 2019; 77(12):2557-66. https://doi.org/10.1016/j.joms.2019.05.008
Sharma S, Hotkar S, Matne A, Vallabhaneni S, Ravipati A, Khandelwal A. Reconstruction of continuity defects of the mandible with non-vascularized bone grafts- Original study. Adv Med Dent Sci Research 2020; 8(11):23-6. https://doi.org/10.21276/jamdsr
Allsopp BJ, Hunter-Smith DJ, Rozen WM. Vascularized versus nonvascularized Bone Grafts: what is the Evidence? Clin Orthop Relat Res 2016; 474(5):1319-27. https://doi.org/10.1007/s11999-016-4769-4
Kerrary S, Schouman T, Cox A, Bertolus C, Febrer G, Bertrand JC. Acute compartment syndrome following fibula flap harvest for mandibular reconstruction. J Craniomaxillofac Surg 2011; 39(3):206-8. https://doi.org/10.1016/j.jcms.2010.03.012
Fodor L, Dinu C, Fodor M, Ciuce C. Severe compartment syndrome following fibula harvesting for mandible reconstruction. Int J Oral Maxillofac Surg 2011; 40(4):443-5. https://doi.org/10.1016/j.ijom.2010.10.021
Brudnicki A, Rachwalski M, Wiepszowski Ł, Sawicka E. Secondary alveolar bone grafting in cleft lip and palate: a comparative analysis of donor site morbidity in different age groups. J Craniomaxillofac Surg 2019; 47(1):165-9. https://doi.org/10.1016/j.jcms.2018.11.006
Katz MS, Ooms M, Heitzer M, Peters F, Winnand P, Kniha K, et al. Postoperative morbidity and complications in elderly patients after harvesting of iliac crest bone grafts. Medicina 2021; 57(8):759. https://doi.org/10.3390/medicina57080759
Lonie S, Herle P, Paddle A, Pradhan N, Birch T, Shayan R. Mandibular reconstruction: meta-analysis of iliac- versus fibula-free flaps. ANZ J Surg 2016; 86(5):337-42. https://doi.org/10.1111/ans.13274
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Pesquisa Brasileira em Odontopediatria e Clínica Integrada
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.