Single Nucleotides Polymorphisms in COX2 Gene and their Association with Signs and Symptoms of Teething – A Pilot Study


  • Alana Gonçalvez Mauta
  • Caio Luiz Bitencourt Reis
  • Vinicius Broska Teodoro
  • Isabela Ribeiro Madalena
  • Christian Kirschneck
  • Peter Proff
  • Aleysson Olimpio Paza
  • Flares Baratto-Filho
  • Daniela Silva Barroso de Oliveira
  • Erika Calvano Küchler
  • João Armando Brancher


Cyclooxygenase 2, Genes, Tooth Eruption


Objective: To investigate the association between single nucleotide polymorphisms in the COX2 gene (rs689466 and rs5275) and local and systemic signs and symptoms of teething. Material and Methods: Forty-four pairs of mothers-babies/toddlers were included. Erupted primary teeth were evaluated during clinical examination. Local and systemic signs and symptoms of teething were obtained from mothers' reporting via anamnesis. Samples of buccal cells were retrieved for DNA genotyping using real-time PCR. The T-test, Chi-square test, logistic regression, and haplotype analyses were applied. Results: Almost all mothers (95.5%) reported at least one local or systemic sign and symptom of teething. The most common was increased salivation (79.5%), diarrhea (72.3%), and fever (70.5%). The mean number of signs and symptoms per child was higher in boys than girls (mean = 5.1; SD= 1.5; p=0.008). Sleep disturbance (p=0.03) and loss of appetite (p=0.05) were more reported in boys. The rs689466 and rs5275 were not associated with signs and symptoms of teething (p>0.05). Conclusion: The single nucleotide polymorphisms in the COX2 gene (rs689466 and rs5275) were not associated with local and systemic signs and symptoms of teething.


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How to Cite

Mauta, A. G., Reis, C. L. B., Teodoro, V. B., Madalena, I. R., Kirschneck, C., Proff, P., Paza, A. O., Baratto-Filho, F., de Oliveira, D. S. B., Küchler, E. C., & Brancher, J. A. (2023). Single Nucleotides Polymorphisms in COX2 Gene and their Association with Signs and Symptoms of Teething – A Pilot Study. Pesquisa Brasileira Em Odontopediatria E Clínica Integrada, 23, e210244. Retrieved from



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