Effect of Non-Surgical Periodontal Therapy on Chronic Kidney Disease Patients: A Systematic Review


  • Ranu Oza
  • Varsha Sharma
  • Mahalaqua Nazli Khatib
  • Prasad Dhadse
  • Pavan Bajaj
  • Kiran Kumar Ganji
  • Rakhi Issrani
  • Mahmoud Gamal Salloum
  • Meshal Abeer Alonazi


Kidney Diseases, Periodontitis, Therapeutics


Objective: To evaluate the effectiveness of “non-surgical periodontal therapy (NSPT)” on periodontal and renal parameters in periodontitis patients diagnosed with chronic kidney disease. Material and Methods: The review protocol has been registered in Prospero (CRD42020150938). Up to November 2019, we searched the PUBMED database without language constraints. We included randomized controlled (parallel-group or cross-over) trials with CKD and chronic periodontitis in adults aged 18 years and above. Three review authors independently assessed the studies. Three review writers gathered data and simultaneously assessed the risk of bias for individual trials using traditional Cochrane procedures. Results: Studies showed high variability. Three randomized clinical trials (RCT) were excluded because of high heterogeneity; meta-analysis could not be performed. Conclusion: Non-surgical periodontal therapy effectively improves periodontal and renal parameters. However, a meta-analysis could not be performed because of the high heterogeneity among the studies.


Balwani MR, Pasari A, Tolani P. Widening spectrum of renal involvement in psoriasis: First reported case of C3 glomerulonephritis in a psoriatic patient. Saudi J Kidney Dis Transplant 2019; 30(1):258-260. https://doi.org/10.4103/1319-2442.252922

Artese HPC, de Sousa CO, Torres MCM de B, Silva-Boghossian CM, Colombo PV. Effect of non-surgical periodontal treatment on the subgingival microbiota of patients with chronic kidney disease. Braz Oral Res 2012; 26(4):366-372. https://doi.org/10.1590/S1806-83242012005000008

Zhang J, Jiang H, Sun M, Chen J. Association between periodontal disease and mortality in people with CKD: A meta-analysis of cohort studies. BMC Nephrol 2017; 18(1):1-11. https://doi.org/10.1186/s12882-017-0680-9

Chavan RS, Bhongade ML, Tiwari IR, Jaiswal P. Open flap debridement in combination with acellular dermal matrix allograft for the prevention of postsurgical gingival recession: A case series. Int J Periodontics Restor Dent 2013; 33(2):217-221. https://doi.org/10.11607/prd.0416

Altamimi A, AlBakr S, Alanazi T, Alshahrani F, Chalisserry E, Anil S. Prevalence of periodontitis in patients undergoing hemodialysis: A case control study. Mater Socio Medica 2018; 30(1):58-61. https://doi.org/10.5455/msm.2018.30.58-61

Willmann DE, Gehrig JS, Matloff RB. Non-surgical periodontal therapy. In: Gehrig JS, Willmann DE. Foundations of Periodontics for the Dental Hygienist. 4th. ed. Philadelphia: Wolters Kluwer; 2015.

Wachter RF, Briggs GP, Pedersen CE. Precipitation of phase I antigen of Coxiella burnetii by sodium sulfite. Acta Virol 1975; 19(6):500.

Jain S, Sharma N. Guideline for systematic reviews. Int Dent Med J Adv Res 2016; 2(1):1-10. https://doi.org/10.15713/ins.idmjar.48

Löe H. The gingival index, the plaque index and the retention index systems. J Periodontol 1967; 38(6):610-616. https://doi.org/10.1902/jop.1967.38.6.610

Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Syst Rev 2016; 5(1):1-10. https://doi.org/10.1186/s13643-016-0384-4

Chaimani A, Caldwell DM, Li T, Higgins JPT, Salanti G. Undertaking network meta-analyses. In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al. Cochrane Handbook for Systematic Reviews of Interventions. 2nd. ed. Chichester (UK): John Wiley & Sons; 2019.

McKenzie JE, Brennan SE, Ryan RE, Thomson HJ, Johnston RV. Chapter 9: Summarizing study characteristics and preparing for synthesis. In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al. Cochrane Handbook for Systematic Reviews of Interventions. 2nd. ed. Chichester (UK): John Wiley & Sons; 2019.

Elbourne DR, Altman DG, Higgins JP, Curtin F, Worthington HV, Vail A. Meta-analyses involving cross-over trials: methodological issues. Int J Epidemiol 2002; 31(1):140-149. https://doi.org/10.1093/ije/31.1.140

Zhao JG. Identifying and measuring heterogeneity across the studies in meta-analysis. J Hand Surg Am 2013; 38(7):1449-1450. https://doi.org/10.1016/j.jhsa.2013.05.020

Basevi V, Lavender T. Routine perineal shaving on admission in labour. Cochrane Database Syst Rev 2014; 2014(11):CD001236. https://doi.org/10.1002/14651858.CD001236.pub2

Fang S, Wang Y, Sui D, Liu H, Ross MI, Gershenwald JE, et al. C-reactive protein as a marker of melanoma progression. J Clin Oncol 2015; 33(12):1389-1396. https://doi.org/10.1200/JCO.2014.58.0209

Artese HPC, de Sousa CO, Luiz RR, Sansone C, Torres MCM de B. Effect of non-surgical periodontal treatment on chronic kidney disease patients. Braz Oral Res 2010; 24(4):449-454. https://doi.org/10.1590/S1806-83242010000400013

Grubbs V, Garcia F, Jue BL, Vittinghoff E, Ryder M, Lovett D, et al. The Kidney and Periodontal Disease (KAPD) study: A pilot randomized controlled trial testing the effect of non-surgical periodontal therapy on chronic kidney disease. Contemp Clin Trials 2017; 53:143-150. https://doi.org/10.1016/j.cct.2016.12.017

Jamieson L, Skilton M, Maple-Brown L, Kapellas K, Askie L, Hughes J, et al. Periodontal disease and chronic kidney disease among Aboriginal adults; An RCT. BMC Nephrol 2015; 16(1):1-8. https://doi.org/10.1186/s12882-015-0169-3

Graziani F, Cei S, La Ferla F, Vano M, Gabriele M, Tonetti M. Effects of non-surgical periodontal therapy on the glomerular filtration rate of the kidney: An exploratory trial. J Clin Periodontol 2010; 37(7):638-643. https://doi.org/10.1111/j.1600-051X.2010.01578.x

Fisher MA, Borgnakke WS, Taylor GW. Periodontal disease is a risk marker in coronary heart disease and chronic kidney disease. Curr Opin Nephrol Hypertens 2010; 19(6):519-526. https://doi.org/10.1097/MNH.0b013e32833eda38

Khalighinejad N, Aminoshariae A, Kulild JC, Williams KA, Wang J, Mickel A. The effect of the dental operating microscope on the outcome of non-surgical root canal treatment: A retrospective case-control study. J Endod 2017; 43(5):728-732. https://doi.org/10.1016/j.joen.2017.01.015




How to Cite

Oza, R., Sharma, V., Khatib, M. N., Dhadse, P., Bajaj, P., Ganji, K. K., Issrani, R., Salloum, M. G., & Alonazi, M. A. (2024). Effect of Non-Surgical Periodontal Therapy on Chronic Kidney Disease Patients: A Systematic Review. Pesquisa Brasileira Em Odontopediatria E Clínica Integrada, 24, e220139. Retrieved from https://revista.uepb.edu.br/PBOCI/article/view/3211



Systematic Reviews (and Meta-Analysis)