Impact of Photobiomodulation during Root Canal Treatment on Oral Health-Related Quality of Life: A Randomized Clinical Trial

Vania Gomes Moraes; Wayne Martins Nascimento; Marcelo Levin Cidade D’Amato Tavares; Ludmila da Silva Guimarães; Erlange Andrade Borges Silva; Fernanda Garcias Hespanhol; Livia Azeredo Alves Antunes; Leonardo dos Santos Antunes

Authors

Vania Gomes Moraes
Wayne Martins Nascimento
Marcelo Levin Cidade D’Amato Tavares
Ludmila da Silva Guimarães
Erlange Andrade Borges Silva
Fernanda Garcias Hespanhol
Livia Azeredo Alves Antunes
Leonardo dos Santos Antunes

Keywords:

Quality of Life, Oral Health; Photochemotherapy, Low-Level Light Therapy, Endodontics

Abstract

Objective: To evaluate the impact of endodontic treatment with photobiomodulation on oral health-related quality of life (HRQoL). Material and Methods: Seventy participants with single-rooted teeth and a diagnosis of asymptomatic apical periodontitis were selected and randomized into two groups: control group (CG, n = 35), root canal treatment without additional treatment, and experimental group (EG, n = 35), root canal treatment associated with antimicrobial photodynamic therapy and low-level laser therapy. OHRQoL was assessed using the Oral Health Impact Profile Questionnaire (OHIP-14) at baseline and 7 and 30 days after treatment. Data were subjected to Wilcoxon, Mann-Whitney tests, and linear regression using the generalized estimating equation model, using the Statistical Package for Social Science software with a significance level of 5%. Results: No statistically significant differences were found between groups regarding sociodemographic and clinical characteristics (p>0.05). There was also no difference in the OHRQoL between the CG and EG (p>0.05). However, there was a statistical difference in OHIP-14 scores between baseline and the 7- and 30-day follow-up intervals in both groups for all domains (p<0.05). Conclusion: Root canal treatment, with or without photobiomodulation, significantly improved the OHRQoL of participants after 7 and 30 days of treatment.

References

WHOQOL Group. The World Health Organization quality of life assessment (WHOQOL): Position paper from the World Health Organization. Soc Sci Med 1995; 41(10):1403-1409. https://doi.org/10.1016/0277-9536(95)00112-k

Karimi M, Brazier J. Health, health-related quality of life, and quality of life: What is the difference? PharmacoEconomics 2016; 34(7):645-649. https://doi.org/10.1007/s40273-016-0389-9

Osman SM, Khalifa N, Alhajj MN. Validation and comparison of the Arabic versions of GOHAI and OHIP-14 in patients with and without denture experience. BMC Oral Health 2018; 18(1):157. https://doi.org/10.1186/s12903-018-0620-5

El Osta N, Tubert-Jeannin S, Hennequin M, Bou Abboud Naaman N, El Osta L, Geahchan N. Comparison of the OHIP-14 and GOHAI as measures of oral health among elderly in Lebanon. Health Qual Life Outcomes 2012; 10:131. https://doi.org/10.1186/1477-7525-10-131

Siqueira JF Jr, Rôças IN. Polymerase chain reaction-based analysis of microorganisms associated with failed endodontic treatment. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004; 97(1):85-94. https://doi.org/10.1016/s1079-2104(03)00353-6

Ricucci D, Siqueira JF Jr. Biofilms and apical periodontitis: Study of prevalence and association with clinical and histopathologic findings. J Endod 2010; 36(8):1277-1288. https://doi.org/10.1016/j.joen.2010.04.007

Borges Silva EA, Guimarães LS, Küchler EC, Antunes LAA, Antunes LS. Evaluation of effect of foraminal enlargement of necrotic teeth on postoperative symptoms: A systematic review and meta-analysis. J Endod 2017; 43(12):1969-1977. https://doi.org/10.1016/j.joen.2017.07.014

Sathorn C, Parashos P, Messer H. The prevalence of postoperative pain and flare-up in single- and multiple-visit endodontic treatment: A systematic review. Int Endod J 2008; 41(2):91-99. https://doi.org/10.1111/j.1365-2591.2007.01316.x

Asnaashari M, Ashraf H, Daghayeghi AH, Mojahedi SM, Azari-Marhabi S. Management of post endodontic retreatment pain with low level laser therapy. J Lasers Med Sci 2017; 8(3):128-131. https://doi.org/10.15171/jlms.2017.23

Arslan H, Doğanay E, Karataş E, Ünlü MA, Ahmed HMA. Effect of low-level laser therapy on postoperative pain after root canal retreatment: A preliminary placebo-controlled, triple-blind, randomized clinical trial. J Endod 2017; 43(11):1765-1769. https://doi.org/10.1016/j.joen.2017.06.028

Coelho MS, Vilas-Boas L, Tawil PZ. The effects of photodynamic therapy on postoperative pain in teeth with necrotic pulps. Photodiagnosis Photodyn Ther 2019; 27:396-401. https://doi.org/10.1016/j.pdpdt.2019.07.002

Barciela B, da Silva Limoeiro AG, Bueno CE, Fernandes SL, Mandarini DR, Boer NC, et al. In vivo evaluation of painful symptomatology after endodontic treatment with or without the use of photodynamic therapy. J Conserv Dent 2019; 22(4):332-335. https://doi.org/10.4103/JCD.JCD_39_19

Prażmo EJ, Godlewska RA, Mielczarek AB. Effectiveness of repeated photodynamic therapy in the elimination of intracanal Enterococcus faecalis biofilm: An in vitro study. Lasers Med Sci 2017; 32(3):655-661. https://doi.org/10.1007/s10103-017-2164-3

Doğanay Yıldız E, Arslan H. Effect of low-level laser therapy on postoperative pain in molars with symptomatic apical periodontitis: A randomized placebo-controlled clinical trial. J Endod 2018; 44(11):1610-1615. https://doi.org/10.1016/j.joen.2018.07.002

Walsh LJ. The current status of low-level laser therapy in dentistry. Part 1. Soft tissue applications. Aust Dent J 1997; 42(4):247-254. https://doi.org/10.1111/j.1834-7819.1997.tb00129.x

Basford JR. Low intensity laser therapy: Still not an established clinical tool. Lasers Surg Med 1995; 16(4):331-342. https://doi.org/10.1002/lsm.1900160404

Antunes LS, Souza CR, Salles AG, Gomes CC, Antunes LA. Does conventional endodontic treatment impact oral health-related quality of life? A systematic review. Eur Endod J 2017; 3(1):2-8. https://doi.org/10.5152/eej.2017.17008

Neelakantan P, Liu P, Dummer PMH, McGrath C. Oral health-related quality of life (OHRQoL) before and after endodontic treatment: A systematic review. Clin Oral Investig 2020; 24(1):25-36. https://doi.org/10.1007/s00784-019-03076-8

Nagendrababu V, Duncan HF, Bjørndal L, Kvist T, Priya E, Jayaraman J, et al. PRIRATE 2020 guidelines for reporting randomized trials in Endodontics: A consensus-based development [published correction appears in Int Endod J 2020; 53(9):1312]. Int Endod J 2020; 53(6):764-773. https://doi.org/10.1111/iej.13294

Liu P, McGrath C, Cheung GS. Improvement in oral health-related quality of life after endodontic treatment: A prospective longitudinal study. J Endod 2014; 40(6):805-810. https://doi.org/10.1016/j.joen.2014.02.008

Guimarães LDS, da Silva EAB, Hespanhol FG, Fontes KBFDC, Antunes LAA, Antunes LS. Effect of photobiomodulation on postoperative symptoms in teeth with asymptomatic apical periodontitis treated with foraminal enlargement: A randomized clinical trial. Int Endod J 2021; 54(10):1708-1719. https://doi.org/10.1111/iej.13593

Cruz Junior JA, Coelho MS, Kato AS, Vivacqua-Gomes N, Fontana CE, Rocha DG, et al. The effect of foraminal enlargement of necrotic teeth with the reciproc system on postoperative pain: A prospective and randomized clinical trial. J Endod 2016; 42(1):8-11. https://doi.org/10.1016/j.joen.2015.09.018

Yaylali IE, Teke A, Tunca YM. The effect of foraminal enlargement of necrotic teeth with a continuous rotary system on postoperative pain: A randomized controlled trial. J Endod 2017; 43(3):359-363. https://doi.org/10.1016/j.joen.2016.11.009

Rôças IN, Provenzano JC, Neves MA, Siqueira JF Jr. Disinfecting effects of rotary instrumentation with either 2.5% sodium hypochlorite or 2% chlorhexidine as the main irrigant: A randomized clinical study. J Endod 2016; 42(6):943-947. https://doi.org/10.1016/j.joen.2016.03.019

Slade GD. Derivation and validation of a short-form oral health impact profile. Community Dent Oral Epidemiol 1997; 25(4):284-290. https://doi.org/10.1111/j.1600-0528.1997.tb00941.x

Oliveira BH, Nadanovsky P. Psychometric properties of the Brazilian version of the Oral Health Impact Profile-short form. Community Dent Oral Epidemiol 2005; 33(4):307-314. https://doi.org/10.1111/j.1600-0528.2005.00225.x

Saini HR, Sangwan P, Sangwan A. Pain following foraminal enlargement in mandibular molars with necrosis and apical periodontitis: A randomized controlled trial. Int Endod J 2016 Dec;49(12):1116-1123. https://doi.org/10.1111/iej.12583

Morse DR, Furst ML, Belott RM, Lefkowitz RD, Spritzer IB, Sideman BH. A prospective randomized trial comparing periapical instrumentation to intracanal instrumentation in cases of asymptomatic pulpal-periapical lesions. Oral Surg Oral Med Oral Pathol 1987; 64(6):734-741. https://doi.org/10.1016/0030-4220(87)90178-2

Oliveira PS, da Costa KNB, Carvalho CN, Ferreira MC. Impact of root canal preparation performed by ProTaper Next or Reciproc on the quality of life of patients: A randomized clinical trial. Int Endod J 2019; 52(2):139-148. https://doi.org/10.1111/iej.12990

Christie MJ, French D, Sowden A, West A. Development of child-centered disease-specific questionnaires for living with asthma. Psychosom Med 1993; 55(6):541-548. https://doi.org/10.1097/00006842-199311000-00010

Diniz-de-Figueiredo FE, Lima LF, Oliveira LS, Bernardino IM, Paiva SM, Faria-E-Silva AL. The impact of two root canal treatment protocols on the oral health-related quality of life: A randomized controlled pragmatic clinical trial. Int Endod J 2020; 53(10):1327-1338. https://doi.org/10.1111/iej.13356

Sutinen S, Lahti S, Nuttall NM, Sanders AE, Steele JG, Allen PF, et al. Effect of a 1-month vs. a 12-month reference period on responses to the 14-item Oral Health Impact Profile. Eur J Oral Sci 2007; 115(3):246-249. https://doi.org/10.1111/j.1600-0722.2007.00442.x

Sil A, Kumar P, Kumar R, Das NK. Selection of control, randomization, blinding, and allocation concealment. Indian Dermatol Online J 2019; 10(5):601-605. https://doi.org/10.4103/idoj.IDOJ_149_19

Metin R, Tatli U, Evlice B. Effects of low-level laser therapy on soft and hard tissue healing after endodontic surgery. Lasers Med Sci 2018; 33(8):1699-1706. https://doi.org/10.1007/s10103-018-2523-8