Prevalence of Dental Anomalies in Deciduous and Permanent Dentition of Cleft Lip and Palate Patients

Authors

  • Bernardo Olsson
  • Letícia Fontanella Fernandes
  • Halina Grossmann Pereira
  • Beatriz Jervásio Silva
  • Nicoly Ghilardi Cardoso
  • Giuseppe Valduga Cruz
  • Caroline de Souza Mendes
  • Rafaela Scariot

Keywords:

Mouth Abnormalities, Jaw Abnormalities, Tooth Abnormalities

Abstract

Objective: To evaluate the association between oral cleft (OC) phenotypes and dental abnormalities (DA) in both permanent and deciduous dentition of patients with Cleft Lip and/or Palate (CL/P). Material and Methods: This cross-sectional study included CL/P patients older than 4 years of age who had orthopantomograms good enough for DA evaluation. The DA evaluated were tooth agenesis, giroversion, root dilaceration, conoidism, fusion, ectopic tooth, concrescence, tooth twinning, and dental transposition. Sample size calculation was performed. The prevalence of DA in deciduous and permanent dentition was reported, both for maxillary and mandibular teeth. Results: A total of 159 patients were included in this study. There was a statistically significant difference in the prevalence of women and men with cleft palate, being cleft palate more prevalent in women (p=0.005). Regarding sexual dimorphism, no statistically significant difference was found between OC phenotypes (p>0.05). Concerning the prevalence of DA in the cleft region, it was observed that DA are more prevalent in permanent dentition (60%) than in deciduous dentition (24%). Conclusion: Oral cleft phenotypes are associated with sex, but dental abnormalities are not, both in permanent and deciduous dentition. The prevalence of dental abnormalities is higher in the cleft region, but mandibular teeth may also be affected. Dental abnormalities in the oral cleft region shows to be more prevalent in permanent dentition than in deciduous dentition.

References

Bernheim N, Georges M, Malevez C, De Mey A, Mansbach A. Embryology and epidemiology of cleft lip and palate. B-ENT 2006; 2(Suppl4):11-19.

Dixon MJ, Marazita ML, Beaty TH, Murray JC. Cleft lip and palate: Understanding genetic and environmental influences. Nat Rev Genet 2011; 12(3):167-178. https://doi.org/10.1038/nrg2933

Panamonta V, Pradubwong S, Panamonta M, Chowchuen B. Global birth prevalence of orofacial clefts: A systematic review. J Med Assoc Thai 2015; 98(Suppl7):S11-21.

Fonseca-Souza G, de Oliveira L, Wambier L, Scariot R, Feltrin-Souza J. Tooth abnormalities associated with non-syndromic cleft lip and palate: Systematic review and meta-analysis. Clin Oral Investig 2022; 26(8):5089-5103. https://doi.org/10.1007/s00784-022-04540-8

Sahoo A, Singh Dheer S, Mahesh P, Goyal P, Sidhu R, Deepalakshmi S. A questionnaire study to assess patients with cleft lip and palate for their oral health-related quality of life. Cureus 2023; 15(5):e38712. https://doi.org/10.7759/cureus.38712

Mendes CS, Santos KMD, Gerber JT, Petroni V, Cordeiro LDS, Kuchler EC, et al. Variation of tooth crown size in cleft lip and palate patients. J Contemp Dent Pract 2023; 24(4):207-213. https://doi.org/10.5005/jp-journals-10024-3497

Nicholls W. Dental anomalies in children with cleft lip and palate in Western Australia. Eur J Dent 2016; 10(2):254-258. https://doi.org/10.4103/1305-7456.178317

Camporesi M, Baccetti T, Marinelli A, Defraia E, Franchi L. Maxillary dental anomalies in children with cleft lip and palate: A controlled study. Int J Paediatr Dent 2010; 20(6):442-450. https://doi.org/10.1111/j.1365-263X.2010.01063.x

Howe B, Cooper M, Vieira A, Weinberg S, Resick J, Nidey N, et al. Spectrum of dental phenotypes in nonsyndromic orofacial clefting. J Dent Res 2015; 94(7):905-912. https://doi.org/10.1177/0022034515588281

Korolenkova MV, Starikova NV, Udalova NV. The role of external aetiological factors in dental anomalies in non-syndromic cleft lip and palate patients. Eur Arch Paediatr Dent 2019; 20(2):105-111. https://doi.org/10.1007/s40368-018-0397-x

Germec-Cakan D, Nur Yilmaz R, Bulut F, Aksoy A. Dental anomalies in different types of cleft lip and palate: Is there any relation? J Craniofac Surg 2018; 29(5):1316-1321. https://doi.org/10.1097/SCS.0000000000004359

Parsaei Y, Uribe F, Steinbacher D. Orthodontics for unilateral and bilateral cleft deformities. Oral Maxillofac Surg Clin North Am 2020; 32(2):297-307. https://doi.org/10.1016/j.coms.2020.01.011

Lewis C, Jacob L, Lehmann C. The primary care pediatrician and the care of children with cleft lip and/or cleft palate. Pediatrics 2017; 139(5):e20170628. https://doi.org/10.1542/peds.2017-0628

Rodrigues R, Fernandes M, Bessa Monteiro A, Furfuro R, Carvalho Silva C, Vardasca R, et al. Are there any solutions for improving the cleft area hygiene in patients with cleft lip and palate? A systematic review. Int J Dent Hyg 2019; 17(2):130-141. https://doi.org/10.1111/idh.12385

Marzouk T, Alves I, Wong C, DeLucia L, McKinney C, Pendleton C, et al. Association between dental anomalies and orofacial clefts: A meta-analysis. JDR Clin Trans Res 2021; 6(4):368-381. https://doi.org/10.1177/2380084420964795

Tannure P, Oliveira C, Maia L, Vieira A, Granjeiro J, Costa Mde C. Prevalence of dental anomalies in nonsyndromic individuals with cleft lip and palate: a systematic review and meta-analysis. Cleft Palate Craniofac J 2012; 49(2):194-200. https://doi.org/10.1597/10-043

Marques L, Ikejiri L, Sganzerla J. Dental changes in patients with cleft lip and palate: a systematic review of the literature. Res Soc Dev 2022; 11(15):e491111537697. https://doi.org/10.33448/rsd-v11i15.37697

Hamasha AA, Al-Khateeb T, Darwazeh A. Prevalence of dilaceration in Jordanian adults. Int Endod J 2002; 35(11):910-912. https://doi.org/10.1046/j.1365-2591.2002.00593.x

Ely NJ, Sherriff M, Cobourne MT. Dental transposition as a disorder of genetic origin. Eur J Orthod 2006; 28(2):145-151. https://doi.org/10.1093/ejo/cji092

Herrera-Atoche JR, Diaz-Morales S, Colome-Ruiz G, Escoffie-Ramirez M, Orellana MF. Prevalence of dental anomalies in a Mexican population. Dent 3000 2014; 2(1):1-5. https://doi.org/10.5195/d3000.2014.25

Machado RA, de Oliveira LQR, Rangel ALCA, Reis SRA, Scariot R, Martelli DRB, et al. Brazilian multiethnic association study of genetic variant interactions among FOS, CASP8, MMP2 and CRISPLD2 in the risk of nonsyndromic cleft lip with or without cleft palate. Dent J 2022; 11(1):7. https://doi.org/10.3390/dj11010007

Bei M. Molecular genetics of tooth development. Curr Opin Genet Dev 2009; 19(5):504-510. https://doi.org/10.1016/j.gde.2009.09.002

Kapdan A, Kustarci A, Buldur B, Arslan D, Kapdan A. Dental anomalies in the primary dentition of Turkish children. Eur J Dent 2012; 6(2):178-183.

AlHudaithi FS, AlDuhayan NA, AlJohani LN, AlJohani SN, AlQarni HS, AlSawadi MH. Prevalence of dental anomalies among orthodontic patients: A retrospective study in Saudi Arabia. Cureus 2023; 15(12):e49893. https://doi.org/10.7759/cureus.49893

Noorollahian M, Nematy M, Dolatian A, Ghesmati H, Akhlaghi S, Khademi GR. Cleft lip and palate and related factors: A 10 years study in university hospitalised patients at Mashhad--Iran. Afr J Paediatr Surg 2015; 12(4):286-290. https://doi.org/10.4103/0189-6725.172576

Bruner G, Montagnana M, Correa CA, Degan VV, Tube CAM. Prevalence of lip and palate cleft in Rio Claro - SP, from 2006 to 2009. Odontol Clín-Cient 2012; 11(2):117-119.

Renugalakshmi A, Vinothkumar TS, Bokhari AM, Almahdi S, Almalki A, Balla SB, et al. Prevalence of dental anomalies and its role in sex estimation among children of Jazan Region, Saudi Arabia. Children 2023; 10(4):759. https://doi.org/10.3390/children10040759

Freitas JAS, Garib DG, Oliveira M, Lauris RCMC, Almeida ALPF, Neves LT, et al. Rehabilitative treatment of cleft lip and palate: Experience of the Hospital for Rehabilitation of Craniofacial Anomalies - USP (HRAC-USP) - Part 2: Pediatric dentistry and orthodontics. J Appl Oral Sci 2012; 20(2):268-281. https://doi.org/10.1590/S1678-77572012000200024

Terry GL, Noujeim M, Langlais RP, Moore WS, Prihoda TJ. A clinical comparison of extraoral panoramic and intraoral radiographic modalities for detecting proximal caries and visualizing open posterior interproximal contacts. Dentomaxillofac Radiol 2016; 45(4):20150159. https://doi.org/10.1259/dmfr.20150159

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Published

2025-01-30

How to Cite

Olsson, B., Fernandes, L. F., Pereira, H. G., Silva, B. J., Cardoso, N. G., Cruz, G. V., Mendes, C. de S., & Scariot, R. (2025). Prevalence of Dental Anomalies in Deciduous and Permanent Dentition of Cleft Lip and Palate Patients. Pesquisa Brasileira Em Odontopediatria E Clínica Integrada, 25, e240051. Retrieved from https://revista.uepb.edu.br/PBOCI/article/view/4260

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Original Articles