Why Use the Oral Assessment Guide to Assess the Oral Cavity in Children Undergoing Antineoplastic Treatment?

Authors

  • Fabio Gomes dos Santos
  • Paula Maria Maracajá Bezerra
  • Claudio Rodrigues Leles
  • Mariana Leonel Martins
  • Paulo Rogério Ferreti Bonan
  • Isabella Lima Arrais Ribeiro
  • Simone Alves Sousa
  • Ana Maria Gondim Valença

Keywords:

Mouth Neoplasms;, Diagnosis, Oral, Pathology, Oral

Abstract

Oral mucositis is the most common adverse effect of cancer treatment and, histologically, consists of direct or indirect damages in the epithelium of the oral mucosa (especially the non-keratinized) and submucosal. Clinically, it manifests as atrophy, swelling, erythema, and ulceration of oral tissue. The appearance of these lesions in the patient generates discomfort/pain, affecting the ability to speak, swallow, and eat. Remarkably, SOM can be observed in the first week of chemotherapy. In addition, patients with OM require medications to control pain and infections, prolonged hospital stays, nutritional support, and the treatment may be interrupted or modified. Moreover, the mucositis experiences of children and young people with cancer and their parents revealed significant functional, psychological and social defiance. Therefore, this condition is as a challenge to pediatric oncologists and pediatric dentists.

References

Santos FG, Bezerra PMM, Limão NP, Santana YNL, Ribeiro ILA, Bonan PRF, et al. Oral mucositis in children with leukemia undergoing chemotherapy: A case series. Pesqui Bras Odontopediatria Clin Integr 2023; 23:e220140. https://doi.org/10.1590/pboci.2023.067

Soares JB, de Farias Gabriel A, Kirschnick LB, Carrard VC, Curra M, Schuch LF, Martins MAT, Martins MD. Oral mucositis assessment in pediatric and adolescent oncological patients: A systematic review. Pediatr Blood Cancer 2025; 72(1):e31388. https://doi.org/10.1002/pbc.31388

Raber-Durlacher JE, Elad S, Barasch A. Oral mucositis. Oral Oncol 2010; 46(6):452-456. https://doi.org/10.1016/j.oraloncology.2010.03.012

Shetty SS, Maruthi M, Dhara V, Arruda JAA, Abreu LG, Mesquita RA, et al. Oral mucositis: Current knowledge and future directions. Dis Mon 2022; 68(5):101300. https://doi.org/10.1016/j.disamonth.2021.101300

Otmani N, Hattad S. Clinical outcome in children with chemotherapy-induced mucositis. Semin Oncol Nurs 2021; 37(3):151160. https://doi.org/10.1016/j.soncn.2021.151160

Docimo R, Anastasio MD, Bensi C. Chemotherapy-induced oral mucositis in children and adolescents: A systematic review. Eur Arch Paediatr Dent 2022; 23(4):501-511. https://doi.org/10.1007/s40368-022-00727-5

Chen CF, Wang RH, Cheng SN, Chang YC. Assessment of chemotherapy-induced oral complications in children with cancer. J Pediatr Oncol Nurs 2004; 21(1):33-39. https://doi.org/10.1177/1043454203259947

Mazhari F, Shirazi AS, Shabzendehdar M. Management of oral mucositis in pediatric patients receiving cancer therapy: A systematic review and meta-analysis. Pediatr Blood Cancer 2019; 66(3):e27403. https://doi.org/10.1002/pbc.27403

Heggie C, Chauhan A, Gray-Burrows K, Day PF, Phillips B. "It's like being chained up": the oral mucositis experiences of children and young people with cancer, their parents, and healthcare professionals - A qualitative study. Arch Dis Child 2025; 110:287-294. https://doi.org/10.1136/archdischild-2024-327529

Braguês R, Marvão MF, Correia P, Silva RM. Oral mucositis management in children under cancer treatment: a systematic review. Cancers 2024; 16(8):1548. https://doi.org/10.3390/cancers16081548

Bardellini E, Majorana A. Oral complications in children undergoing chemotherapy: The COMEDY (Clenching, Oral Mucositis, Eyes, DYsphagia) Pattern. J Pediatr Hematol Oncol 2019; 41(3):249. https://doi.org/10.1097/MPH.0000000000001347

Gibson F, Auld EM, Bryan G, Coulson S, Craig JV, Glenny AM. A systematic review of oral assessment instruments: what can we recommend to practitioners in children's and young people's cancer care? Cancer Nurs 2010; 33(4):E1-E19. https://doi.org/10.1097/NCC.0b013e3181cb40c0

de Farias Gabriel A, Silveira FM, Curra M, Schuch LF, Wagner VP, Martins MAT, et al. Risk factors associated with the development of oral mucositis in pediatric oncology patients: Systematic review and meta-analysis. Oral Dis 2022;28(4):1068-1084. https://doi.org/10.1111/odi.13863

Bezerra PMM, Sampaio MEA, Dos Santos FG, Ribeiro ILA, Santiago BM, de Sousa SA, et al. The effectiveness of an oral health education and prevention program on the incidence and severity of oral mucositis in pediatric cancer patients: A non-randomized controlled study. Support Care Cancer 2021; 29(12):7877-7885. https://doi.org/10.1007/s00520-021-06387-3

Miranda-Silva W, Gomes-Silva W, Zadik Y, Yarom N, Al-Azri AR, Hong CHL, et al. MASCC/ISOO clinical practice guidelines for the management of mucositis: sub-analysis of current interventions for the management of oral mucositis in pediatric cancer patients. Support Care Cancer 2021;29(7):3539-3562. https://doi.org/10.1007/s00520-020-05803-4

Eilers J, Berger AM, Petersen MC. Development, testing, and application of the oral assessment guide. Oncol Nurs Forum 1988;15(3):325-330.

Cheng KK, Lee V, Li CH, Yuen HL, Epstein JB. Oral mucositis in pediatric and adolescent patients undergoing chemotherapy: The impact of symptoms on quality of life. Support Care Cancer 2012; 20(10):2335-2342. https://doi.org/10.1007/s00520-011-1343-1

Kamsvåg-Magnusson T, Thorsell-Cederberg J, Svanberg A, von Essen L, Arvidson J, Mellgren K, et al. Parents and children's perceptions of distress related to oral mucositis during haematopoietic stem cell transplantation. Acta Paediatr 2014; 103(6):630-636. https://doi.org/10.1111/apa.12627

Gibson F, Cargill J, Allison J, Begent J, Cole S, Stone J, et al. Establishing content validity of the oral assessment guide in children and young people. Eur J Cancer 2006; 42(12):1817-1825. https://doi.org/10.1016/j.ejca.2006.02.018

Cheng KK, Chang AM, Yuen MP. Prevention of oral mucositis in paediatric patients treated with chemotherapy: A randomised crossover trial comparing two protocols of oral care. Eur J Cancer 2004; 40:1208-1216. https://doi.org/10.1016/j.ejca.2003.10.023

Triarico S, Agresti P, Rinninella E, Mele MC, Romano A, Attinà G, et al. Oral microbiota during childhood and its role in chemotherapy-induced oral mucositis in children with cancer. Pathogens 2022; 11(4):448. https://doi.org/10.3390/pathogens11040448

Costa RC, Bezerra PMM, Damascena LCL, Ribeiro ILA, Bonan PRF, de Sousa SA, et al. Impact of saliva and cariogenic microbiota on the chemotherapy-induced oral mucositis in oncopediatric patients: A preliminary longitudinal study. Int J Dent 2020; 2020:1243953. https://doi.org/10.1155/2020/1243953

Pimenta Amaral TM, Campos CC, Moreira dos Santos TP, Leles CR, Teixeira AL, Teixeira MM, et al. Effect of salivary stimulation therapies on salivary flow and chemotherapy-induced mucositis: a preliminary study. Oral Surg Oral Med Oral Pathol Oral Radiol 2012; 113(5):628-637. https://doi.org/10.1016/j.oooo.2011.10.012

Jensen SB, Vissink A, Limesand KH, Reyland ME. Salivary Gland hypofunction and xerostomia in head and neck radiation patients. J Natl Cancer Inst Monogr 2019; 2019(53):lgz016. https://doi.org/10.1093/jncimonographs/lgz016

Jensen SB, Pedersen AM, Reibel J, Nauntofte B. Xerostomia and hypofunction of the salivary glands in cancer therapy. Support Care Cancer 2003; 11(4):207-225. https://doi.org/10.1007/s00520-002-0407-7

Yarom N, Hovan A, Bossi P, Ariyawardana A, Jensen SB, Gobbo M, et al. Systematic review of natural and miscellaneous agents, for the management of oral mucositis in cancer patients and clinical practice guidelines - part 2: honey, herbal compounds, saliva stimulants, probiotics, and miscellaneous agents. Support Care Cancer 2020; 28(5):2457-2472. https://doi.org/10.1007/s00520-019-05256-4

Pels EJ. Oral mucositis and saliva IgA, IgG and IgM concentration during anti-tumor treatment in children suffering from acute lymphoblastic leukemia. Adv Clin Exp Med 2017; 26(9):1351-1358. https://doi.org/10.17219/acem/64940

Sonis ST. Pathobiology of oral mucositis: novel insights and opportunities. J Support Oncol 2007; 5(9 Suppl 4):3-11.

Mercadante S, Aielli F, Adile C, Ferrera P, Valle A, Fusco F, et al. Prevalence of oral mucositis, dry mouth, and dysphagia in advanced cancer patients. Support Care Cancer 2015; 23(11):3249-3255. https://doi.org/10.1007/s00520-015-2720-y

Guimarães JR, Carvalho LG, Damascena LC, Sampaio ME, Ribeiro IL, Sousa SA, et al. The incidence of severe oral mucositis and its occurrence sites in pediatric oncologic patients. Med Oral Patol Oral Cir Bucal 2021; 26(3):e299-e303. https://doi.org/10.4317/medoral.24185

Tomlinson D, Judd P, Hendershot E, Maloney AM, Sung L. Establishing literature-based items for an oral mucositis assessment tool in children. J Pediatr Oncol Nurs 2008; 25(3):139-147. https://doi.org/10.1177/1043454208317235

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Published

2025-03-26

How to Cite

Santos, F. G. dos, Bezerra, P. M. M., Leles, C. R., Martins, M. L., Bonan, P. R. F., Ribeiro, I. L. A., Sousa, S. A., & Valença, A. M. G. (2025). Why Use the Oral Assessment Guide to Assess the Oral Cavity in Children Undergoing Antineoplastic Treatment?. Pesquisa Brasileira Em Odontopediatria E Clínica Integrada, 25, e250051. Retrieved from https://revista.uepb.edu.br/PBOCI/article/view/4398

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Letters to the Editor