Potential Effectiveness of Poly-Vitamins and Probiotics among Preschool Children Living within Iodine Deficiency Territory to Caries Prevention


  • Oksana I. Godovanets
  • Anastasiia V. Kotelban
  • Liudmyla Hrynkevych
  • D. G. Romaniuk
  • Larisa Ya. Fedoniuk


Child, Preschool, Preventive Dentistry, Dental Caries


Objective: To evaluate the potential effect of poly-vitamins and probiotics use among preschool children permanently living within iodine deficiency territory on caries prevention. Material and Methods: 80 children aged 2-3 years old were randomly distributed among the study group (21 male and 19 females) and control group (20 males and 20 females). Oral fluid samples were formed from each study subject during primary examination and after 1 year of monitoring, which further were analyzed by parameters associated with mineralization potential of oral fluid. Both groups were provided with oral hygiene educational training, while the study group was also prescribed with poly-vitamin-mineral drug complex and probiotics. Results: After 1 year of monitoring, no significant changes considering caries prevalence (p>0.05) or intensity (p>0.05) values were registered among study and control groups. Difference of free calcium level, phosphate ion level and alkaline phosphatase activity was statistically approved (p<0.05) while comparing between study and control group after 12 months of monitoring. Conclusion: Caries preventive approach consisted of oral hygiene educational training and course of properly prescribed poly-vitamins and probiotics intake demonstrates positive results related to the changes within mineralization potential of oral fluid among preschool children with long-term residence over geographically associated iodine-deficient territory.


Kassebaum NJ, Smith AGC, Bernabé E, Fleming TD, Reynolds AE, Vos T, et al. Global, Regional, and National Prevalence, Incidence, and Disability-Adjusted Life Years for Oral Conditions for 195 Countries, 1990-2015: A Systematic Analysis for the Global Burden of Diseases, Injuries, and Risk Factors. J Dent Res 2017; 96(4):361-3. https://doi.org/10.1177/0022034517693566

Anil S, Anand PS. Early childhood caries: prevalence, risk factors, and prevention. Front Pediatr 2017; 5:157. https://doi.org/10.3389/fped.2017.00157

Cherepiuk O, Stadnyk P. The level of dental care for children in preschool institutions in Ivano-Frankivsk. Ukrainian Dental Almanac 2016; 1(1):87-9.

Klitynska OV, Kostenko YY, Gurando VR. Determination of the criteria of early caries diagnostics in children of different ethnic groups domiciled in areas biogeochemically deficient in fluorine and iodine. J Stomatol 2017; 70(1):51-6. https://doi.org/10.5604/01.3001.0010.1778

Klitynska OV, Kostenko Y, Mukhina YA, Vasko A, Layosh N. Efficiency estimation of using phased program of caries prevention in children domiciled in Transcarpathian region. Acta Stomatol Naissi 2016; 32(74):1635-49. https://doi.org/10.5937/asnl674635K

Goncharuk-Khomyn MY, Melnychuk NI, Yavuz I, Melnychuk DV. Comparative analysis of the major dental pathologies prevalence among children of transcarpathian region according to the data of the studied clinical sample and preliminary performed dental research. Bull Sci Res 2018; 4:152-6. https://doi.org/10.11603/2415-8798.2018.4.9802

Tkachenko IM, Brailko NN, Kovalenko VV, Nazarenko ZJ, Sheshukova OV. Morphological study of enamel and dentin teeth with carious process and non-carious lesions. Wiad Lek 2018; 71(5):1002-5.

Trufanova V, Sheshukova O, Davydenko V, Polishchuk T, Bauman S, Dobroskok V. Characteristics of epidemiology of dental caries in children from regions with high and optimum fluorine content in drinking water. Wiad Lek 2018; 71(2 pt 2):335-8.

Sheshukova OV, Trufanova VP, Polishchuk TV, Kazakova KS, Bauman SS, Lyakhova NA, et al. Monitoring of efficiency of dental caries management in children's temporary teeth throughout Poltava oblast. Wiad Lek 2018; 71(3 pt 2):761-7.

Кaskova LF, Маndziuk ТB, Ulasevych LP, Kuzniak NB. Physical indices of the oral fluid in children with caries and intact teeth at different age periods. Wiad Lek 2019; 72(5 cz 2):1048-105.

Khomenko L, Оstapko О, Bidenko N, Golubeva І. Influence of environment on oral health status of children in Ukraine. Med Sci Ukraine 2016; 12(1-2):51-8.

Narepekha OT, Dubetska-Hrabous IS. The state of hard tissue of temporary teeth in children from orphanages and boarding-schools. Ukrainian Dent Almanac 2016;1(3):100-3.

Skrīvele S, Care R, Bērziņa S, Kneist S, de Moura-Sieber V, de Moura R, et al. Caries and its risk factors in young children in five different countries. Stomatologija 2013; 15(2):39-46.

Dmitriev MO, Gunas IV, Dzevulska IV, Zhulkevych IV. Determination of individual cephalometric characteristics of the occlusal plane in Ukrainian young men and young women withorthognatic bite. Biomed Biosocial Anthropol 2018; 33:5-11. https://doi.org/10.31393/bba33-2018-01

Goncharuk-Khomyn M, Akleyin E, Zhulkevych I, Nahirnyi Y, Brekhlichuk P, Mochalov Y, et al. Correspondence between dental and skeletal maturity parameters among patients with different sagittal relationships at the end of puberty period. J Int Dent Med Res 2020; 13(1):223-8.

Rong WS, Bian JY, Wang WJ, De Wang J. Effectiveness of an oral health education and caries prevention program in kindergartens in China. Community Dent Oral Epidemiol 2003; 31(6):412-6. https://doi.org/10.1046/j.1600-0528.2003.00040.x

Kang BH, Park SN, Sohng KY, Moon JS. Effect of a tooth-brushing education program on oral health of preschool children. J Korean Acad Nurs 2008; 38(6):914-22. https://doi.org/10.4040/jkan.2008.38.6.914

Cagetti MG, Mastroberardino S, Milia E, Cocco F, Lingström P, Campus G. The use of probiotic strains in caries prevention: a systematic review. Nutrients 2013; 5(7):2530-50. https://doi.org/10.3390/nu5072530

Poorni S, Srinivasan MR, Nivedhitha MS. Probiotic Streptococcus strains in caries prevention: a systematic review. J Conserv Dent 2019; 22(2):123-8. https://doi.org/10.4103/JCD.JCD_505_18

Jørgensen MR, Castiblanco G, Twetman S, Keller MK. Prevention of caries with probiotic bacteria during early childhood. Promising but inconsistent findings. Am J Dent 2016; 29(3):127-31.

Seminario-Amez M, López-López J, Estrugo-Devesa A, Ayuso-Montero R, Jané-Salas E. Probiotics and oral health: a systematic review. Med Oral Patol Oral Cir Bucal 2017; 22(3):e282-e288. https://doi.org/10.4317/medoral.21494

Cagetti MG, Wolf TG, Tennert C, Camoni N, Lingström P, Campus G. The role of vitamins in oral health. A systematic review and meta-analysis. Int J Environ Res Public Health 2020; 17(3):938. https://doi.org/10.3390/ijerph17030938

Drury TF, Horowitz AM, Ismali AI, Maertens MP, Rozier G, Selwitz RH. Diagnosing and reporting early childhood caries for research purposes. J Public Health Dent 1999; 59(3):192-7. https://doi.org/10.1111/j.1752-7325.1999.tb03268.x

Chandran T, Ravindranath NS, Kumari D, Tirupati N, Mithun K, Shilpa M, et al. Oral health education intervention among preschoolers: a randomized controlled trial. Indian J Public Health Res Dev 2019; 10(9):363-8. https://doi.org/10.5958/0976-5506.2019.02453.7

Bilyshchuk L, Keniuk A, Goncharuk-Khomyn M, Yavuz I. Association between saliva quantity and content parameters with caries intensity levels: a cross-sectional study among subcarpathian children. Pesqui Bras Odontopediatria Clín Integr 2019; 19:e5048. https://doi.org/10.4034/pboci.2019.191.121

Omer ZQ, Khoshnaw BA. Evaluation of salivary calcium, phosphorus and alkaline phosphatase level in children (4-6 years) with nursing caries in Erbil City. Zanco J Med Sci 2017; 21(3):1943-52. https://doi.org/10.15218/zjms.2017.055

Vijayaprasad KE, Ravichandra KS, Vasa AA, Suzan S. Relation of salivary calcium, phosphorus and alkaline phosphatase with the incidence of dental caries in children. J Indian Soc Pedod Prev Dent 2010; 28(3):156-61. https://doi.org/10.4103/0970-4388.73789

SuperVit pills. Available from: https://compendium.com.ua/info/170486/supervit/ [Accessed on July 12, 2020].

BioGaia Prodentis lozenges. Available from: https://www.biogaia.com/product/biogaia-prodentis-lozenges/ [Accessed on July 12, 2020].

Hannigan A, Lynch CD. Statistical methodology in oral and dental research: pitfalls and recommendations. J Dent 2013; 41(5):385-92. https://doi.org/10.1016/j.jdent.2013.02.013

Hegde MN, Attavar SH, Shetty N, Hegde ND, Hegde NN. Saliva as a biomarker for dental caries: a systematic review. J Conserv Dent 2019; 22(1):2-6. https://doi.org/10.4103/JCD.JCD_531_18

Villavicencio J, Villegas LM, Arango MC, Arias S, Triana F. Effects of a food enriched with probiotics on Streptococcus mutans and Lactobacillus spp. salivary counts in preschool children: a cluster randomized trial. J Appl Oral Sci 2018; 26:e20170318. https://doi.org/10.1590/1678-7757-2017-0318

Chu CH, Ho PL, Lo EC. Oral health status and behaviours of preschool children in Hong Kong. BMC Public Health 2012; 12:767. https://doi.org/10.1186/1471-2458-12-767

Hujoel PP, Hujoel MLA, Kotsakis GA. Personal oral hygiene and dental caries: a systematic review of randomised controlled trials. Gerodontology 2018; 35(4):282-9. https://doi.org/10.1111/ger.12331

Sigaud CHS, Santos BR, Costa P, Toriyama ATM. Promoting oral care in the preschool child: effects of a playful learning intervention. Rev Bras Enferm 2017; 70(3):519-25. https://doi.org/10.1590/0034-7167-2016-0237

Calcagnile F, Pietrunti D, Pranno N, Di Giorgio G, Ottolenghi L, Vozza I. Oral health knowledge in pre-school children: A survey among parents in central Italy. J Clin Exp Dent 2019; 11(4):e327-e333. https://doi.org/10.4317/jced.55378

Corchuelo Ojeda J, Soto L. Evaluation of oral hygiene in pre-school children through bacterial plaque supervision by parents. Rev Fac Odontol Univ Antioq 2014; 25(2):313-24.




How to Cite

Godovanets, O. I. ., Kotelban, A. V. ., Hrynkevych, L. ., Romaniuk, D. G. ., & Fedoniuk, L. Y. . (2021). Potential Effectiveness of Poly-Vitamins and Probiotics among Preschool Children Living within Iodine Deficiency Territory to Caries Prevention. Pesquisa Brasileira Em Odontopediatria E Clínica Integrada, 21, e0167. Retrieved from https://revista.uepb.edu.br/PBOCI/article/view/649



Original Articles