Correlation Between Clinical and Histopathologic Diagnosis of Oral Potentially Malignant Disorder and Oral Squamous Cell Carcinoma
Keywords:Pathology, Oral, Mouth Neoplasms, Carcinoma, Squamous Cell, Leukoplakia, Oral
Objective: To determine the frequency of oral potentially malignant disorders and Oral Squamous Cell Carcinoma (OSCC) and evaluate the consistency between their clinical and pathological features. Material and Methods: This retrospective study was conducted on records with a diagnosis of oral leukoplakia, oral erythroplakia, erythroleukoplakia, actinic cheilitis, lichen planus, and OSCC in the Pathology Department of Kerman dental school from September 1997 to September 2017. Data were analyzed in SPSS 21 at the significance level of ≤5%. Results: There were 378 cases of oral potentially malignant disorders and 70 cases of OSCC with a mean age of 46.82 ± 15.24 years. Buccal mucosa was the most frequent site, and lichen planus the most common lesion. Females were significantly older than males in leukoplakia and carcinoma in situ lesions. Clinical diagnosis and histopathology were consistent in 69.03% of cases. Conclusion: Clinical and histopathological diagnoses were consistent in 69.03% of records. The highest degree of clinical compliance with histopathology was observed in OSCC. Dentists should pay attention to oral potentially malignant disorders for early diagnosis to prevent their transformation to malignancy.
Dineshkumar T, Ashwini BK, Rameshkumar A, Rajashree P, Ramya R, Rajkumar K. Salivary and serum interleukin-6 levels in oral premalignant disorders and squamous cell carcinoma: diagnostic value and clinicopathologic correlations. Asia Pac J cancer Prev 2016; 17(11):4899-4906. https://doi.org/10.22034/APJCP.2016.17.11.4899
Pałasz P, Adamski L, Górska-Chrząstek M, Starzyńska A, Studniarek M. Contemporary diagnostic imaging of oral squamous cell carcinoma – a review of literature. Pol J Radiol 2017; 82:193-202. https://doi.org/10.12659/PJR.900892
Carreras-Torras C, Gay-Escoda C. Techniques for early diagnosis of oral squamous cell carcinoma: Systematic review. Med Oral Patol Oral Cir Bucal 2015; 20(3):e305-e315. https://doi.org/10.4317/medoral.20347
Remmerbach TW, Meyer-Ebrecht D, Aach T, Würflinger T, Bell AA, Schneider TE, et al. Toward a multimodal cell analysis of brush biopsies for the early detection of oral cancer. Cancer 2009; 117(3):228-35. https://doi.org/10.1002/cncy.20028
Narayan TV, Shilpashree S. Meta-analysis on clinicopathologic risk factors of leukoplakias undergoing malignant transformation. J Oral Maxillofac Pathol 2016; 20(3):354-61. https://doi.org/10.4103/0973-029X.190900
Rethman MP, Carpenter W, Cohen EE, Epstein J, Evans CA, Flaitz CM, et al. Evidence-based clinical recommendations regarding screening for oral squamous cell carcinomas. J Am Dent Assoc 2010; 141(5):509-20. https://doi.org/10.14219/jada.archive.2010.0223
Sloan P. Squamous cell carcinoma and precursor lesions: clinical presentation. Periodontol 2000 2011; 57(1):10-8. https://doi.org/10.1111/j.1600-0757.2011.00391.x
Warnakulasuriya S, Johnson NW, van der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med 2007; 36(10):575-80. https://doi.org/10.1111/j.1600-0714.2007.00582.x
Jeddy N, Ravi S, Radhika T. Screening of oral potentially malignant disorders: Need of the hour. J Oral Maxillofac Pathol 2017; 21(3):437-8. https://doi.org/10.4103/jomfp.JOMFP_217_17
Bokor-Bratíc M, Vucković N, Mirković S. Correlation between clinical and histopathologic diagnosis of potentially malignant oral lesions. Arch Oncol 2004; 12(3):145-7. https://doi.org/10.2298/AOO0403145B
Maia HC, Pinto NA, Pereira J dos S, de Medeiros AM, da Silveira ÉJ, Miguel MC. Potentially malignant oral lesions: clinicopathological correlations. Einstein 2016; 14(1):35-40. https://doi.org/10.1590/S1679-45082016AO3578
Abbey LM, Kaugars GE, Gunsolley JC, Burns JC, Page DG, Svirsky JA, et al. Intraexaminer and interexaminer reliability in the diagnosis of oral epithelial dysplasia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995; 80(2):188-91. https://doi.org/10.1016/s1079-2104(05)80201-x
Eversole LR. Evidence-based practice of oral pathology and oral medicine. J Calif Dent Assoc 2006; 34(3):448-54.
Torabi M, Shahravan A, Bahabin A, Mohammadzadeh I, Afshar MK. Internet addiction among Iranian students of medical sciences. Pesqui Bras Odontopediatria Clín Integr 2020; 20:e5387. https://doi.org/10.1590/pboci.2020.056
Afshar MK, Torabi M, Bahremand M, Afshar MK, Najmi F, Mohammadzadeh I. Oral health literacy and related factors among pregnant women referring to Health Government Institute in Kerman, Iran. Pesqui Bras Odontopediatria Clín Integr 2020; 20:e5337. https://doi.org/10.1590/pboci.2020.011
Zihayat B, Khodadadi A, Torabi M, Mehdipour M, Basiri M, Asadi-Shekarri M. Wound healing activity of sheep's bladder extracellular matrix in diabetic rats. Biomed Eng: Appl Basis Commun 2018; 30(2):1850015. https://doi.org/10.4015/S1016237218500151
Moro A, Di Nardo F, Boniello R, Marianetti TM, Cervelli D, Gaspardini G, et al. Autofluorescence and early detection of mucosal lesions in patients at risk for oral cancer. J Craniofac Surg 2010; 21(6):1899-903. https://doi.org/10.1097/SCS.0b013e3181f4afb4
Rana M, Zapf A, Kuehle M, Gellrich NC, Eckardt AM. Clinical evaluation of an autofluorescence diagnostic device for oral cancer detection: a prospective randomized diagnostic study. Eur J Cancer Prev 2012; 21(5):460-6. https://doi.org/10.1097/CEJ.0b013e32834fdb6d
Mehrotra R, Pandya SH, Chaudhary AK, Kumar M, Singh M. Prevalence of Oral Pre-malignant and Malignant Lesions at a Tertiary Level Hospital in Allahabad, India. Asian Pacific J Cancer Prev 2008; 9(2):263-266.
Casparis S, Borm JM, Tektas S, Kamarachev J, Locher MC, Damerau G, et al. Oral lichen planus (OLP), oral lichenoid lesions (OLL), oral dysplasia, and oral cancer: retrospective analysis of clinicopathological data from 2002-2011. Oral Maxillofac Surg 2015; 19(2):149-56. https://doi.org/10.1007/s10006-014-0469-y.
Silveira ÉJ, Lopes MF, Silva LM, Ribeiro BF, Lima KC, Queiroz LM. Potentially malignant oral lesions: clinical and morphological analysis of 205 cases. J Bras Patol Med Lab 2009; 45(3):233-8. https://doi.org/10.1590/S1676-24442009000300008.
Feller L, Lemmer J. Oral Leukoplakia as It Relates to HPV Infection: A Review. Int J Dent 2012; 2012:540561. https://doi.org/10.1155/2012/540561.
Haas Jr. OL, Rosa FM, Burzlaff JB, Rados PV, Sant’Ana Filho M. Definition of risk group for oral leukoplakia: retrospective study between the years 1999 and 2009. Rev Fac Odont 2011; 16(3):261-6.
Martins RB, Giovani EM, Villalba H. Lesions considered malignant that affect the mouth. Rev Inst Ciênc Saúde. 2008; 26(4):467-76.
Fitzpatrick SG, Hirsch SA, Gordon SC. The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review. J Am Dent Assoc 2014; 145(1):45-56. https://doi.org/10.14219/jada.2013.10.
Soares MS, Honório AP, Arnaud RR, Oliveira Filho FD. Oral conditions in patients with oral lichen planus. Pesq Bras Odontoped Clin Integr 2012; 11(4):507-10. https://doi.org/10.4034/pboci.v11i4.1024.
Sousa FA, Rosa LE. Oral lichen planus cases epidemic profile from Oral Pathology Discipline from FOSJC – UNESP. Cienc Odont Bras 2005; 8(4):96-100.
Idris A, Vani N, Saleh S, Tubaigy F, Alharbi F, Sharwani A, et al. Relative frequency of oral malignancies and oral precancer in the biopsy service of Jazan province, 2009-2014. Asian Pac J Cancer Prev 2016; 17(2):519-25. https://doi.org/10.7314/apjcp.2016.17.2.519
Pereira J dos S, Carvalho M de V, Henriques AC, de Queiroz Camara TH, Miguel MC, Freitas R de A. Epidemiology and correlation of the clinicopathlogical features in oral epitelial displasia: Analysis of 173 cases. Ann Diagn Pathol 2011; 15(2):98-102. https://doi.org/10.1016/j.anndiagpath.2010.08.008
Sciubba JJ. Oral cancer: The importance of early diagnosis and treatment. Am J Clin Dermatol 2001; 2(4):239-51. https://doi.org/10.2165/00128071-200102040-00005
Hanken H, Kraatz J, Smeets R, Heiland M, Assaf AT, Blessmann M, et al. The detection of oral pre- malignant lesions with an autofluorescence based imaging system (VELscope™) - a single blinded clinical evaluation. Head Face Med 2013; 9:23. https://doi.org/10.1186/1746-160X-9-23
Vázquez-Álvarez R, Fernández-González F, Gándara-Vila P, Reboiras-López D, García-García A, Gándara-Rey JM. Correlation between clinical and pathologic diagnosis in oral leukoplakia in 54 patients. Med Oral Patol Oral Cir Bucal 2010; 15(6):e832-8.
Villa A, Woo SB. Leukoplakia - A diagnostic and management algorithm. J Oral Maxillofac Surg 2017; 75(4):723-34. https://doi.org/10.1016/j.joms.2016.10.012
Natekar M, Raghuveer HP, Rayapati DK, Shobha ES, Prashanth NT, Rangan V, et al. A comparative evaluation: Oral leukoplakia surgical management using diode laser, CO2 laser, and cryosurgery. J Clin Exp Dent 2017; 9(6):e779-84. https://doi.org/10.4317/jced.53602.
Müller S. Oral lichenoid lesions: distinguishing the benign from the deadly. Mod Pathol 2017; 30(s1):S54-S67. https://doi.org/10.1038/modpathol.2016.121
Abidullah M, Raghunath V, Karpe T, Akifuddin S, Imran S, Dhurjati VN, et al. Clinicopathologic correlation of white, non scrapable oral mucosal surface lesions: a study of 100 cases. J Clin Diagn Res 2016; 10(2):ZC38-41. https://doi.org/10.7860/JCDR/2016/16950.7226
Nevil BW, Damm DD, Allen CM, Chi AC. Dermatologic Diseases. In.: Nevil BW, Damm DD, Allen CM, Chi AC Oral and Maxillofacial Pathology. 4th. ed. Philadelphia: W. B. Saunders Co.; 2016. Chapter 16; pp. 673-677.
Powsner SM, Costa J, Homer RJ. Clinicians are from Mars and pathologists are from Venus. Arch Pathol Lab Med 2000; 124(7):1040-6.
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