What are the Systemic Factors Associated with the Molar-Incisor Hypomineralization Etiology?

Gabriela  Fonseca-Souza; Aluhê Lopes  Fatturi; Fabian Calixto  Fraiz; Luciana Reichert da Silva  Assunção; Juliana  Feltrin-Souza

Authors

Gabriela Fonseca-Souza
Aluhê Lopes Fatturi
Fabian Calixto Fraiz
Luciana Reichert da Silva Assunção
Juliana Feltrin-Souza

Keywords:

Epidemiology, Tooth Abnormalities, Dental Enamel Hypoplasia, Molar

Abstract

Objective: To evaluate the systemic factors associated with Molar-Incisor Hypomineralization (MIH) etiology. Material and Methods: A total of 731 8-year-old schoolchildren enrolled in the public school system in Curitiba, Brazil, was randomly selected. The MIH diagnosis was performed by calibrated examiners (Kappa >0.80) according to the European Academy of Pediatric Dentistry criteria (2003). The systemic factors were collected through a semi-structured questionnaire and applied to the children’s mothers, addressing the medical history from pregnancy to the first three years of children’s life. Associations were analyzed by Poisson regression analysis with robust variance (p<0.05). Results: The systemic factors in the prenatal and perinatal periods were not associated with MIH (p>0.05). The children who used medications during the first years of life had a significantly higher prevalence of MIH (PRc = 2.18 CI = 95% 1.06–4.48; p=0.033). Conclusion: The use of medications during the first three years of children’s life is associated with a higher prevalence of MIH.

References

FDI Comission. A review of the developmental defects of enamel index (DDE Index). Commission on Oral Health, Research & Epidemiology. Report of an FDI Working Group. Int Dent J 1992; 42(6):411-26.

Alaluusua S. Aetiology of Molar-Incisor Hypomineralisation: A systematic review. Eur Arch Paediatr Dent 2010; 11(2):53-8. https://doi.org/10.1007/bf03262713

Weerheijm KL, Jälevik B, Alaluusua S. Molar-incisor hypomineralisation. Caries Res 2001; 35(5):390-1. https://doi.org/10.1159/000047479

Weerheijm KL. Molar incisor hypomineralisation (MIH). Eur J Paediatr Dent 2003; 4(3):114-20.

Fagrell TG, Dietz W, Jälevik B, Norén JG. Chemical, mechanical and morphological properties of hypomineralized enamel of permanent first molars. Acta Odontol Scand 2010; 68(4):215-22. https://doi.org/10.3109/00016351003752395

Fragelli CM, Jeremias F, Feltrin de Souza J, Paschoal MA, de Cássia Loiola Cordeiro R, Santos-Pinto L. Longitudinal evaluation of the structural integrity of teeth affected by molar incisor hypomineralisation. Caries Res 2015; 49(4):378-83. https://doi.org/10.1159/000380858

Fatturi AL, Wambier LM, Chibinski AC, Assunção L, Brancher JA, Reis A, et al. A systematic review and meta-analysis of systemic exposure associated with molar incisor hypomineralization. Community Dent Oral Epidemiol 2019; 47(5):407-15. https://doi.org/10.1111/cdoe.12467

Silva MJ, Scurrah KJ, Craig JM, Manton DJ, Kilpatrick N. Etiology of molar incisor hypomineralization - A systematic review. Community Dent Oral Epidemiol 2016; 44(4):342-53. https://doi.org/10.1111/cdoe.12229

Serna C, Vicente A, Finke C, Ortiz AJ. Drugs related to the etiology of molar incisor hypomineralization: a systematic review. J Am Dent Assoc 2016; 147(2):120-30. https://doi.org/10.1016/j.adaj.2015.08.011

Wu X, Wang J, Li YH, Yang ZY, Zhou Z. Association of molar incisor hypomineralization with premature birth or low birth weight: systematic review and meta-analysis. J Matern Fetal Neonatal Med 2020; 33(10):1700-8. https://doi.org/10.1080/14767058.2018.1527310

Crombie F, Manton D, Kilpatrick N. Aetiology of molar-incisor hypomineralization: a critical review. Int J Paediatr Dent 2009; 19(2):73-83. https://doi.org/10.1111/j.1365-263X.2008.00966.x

Kılınç G, Çetin M, Köse B, Ellidokuz H. Prevalence, aetiology, and treatment of molar incisor hypomineralization in children living in Izmir City (Turkey). Int J Paediatr Dent 2019; 29(6):775-82. https://doi.org/10.1111/ipd.12508

Reyes MRT, Fatturi AL, Menezes J, Fraiz FC, Assunção L, Souza JF. Demarcated opacity in primary teeth increases the prevalence of molar incisor hypomineralization. Braz Oral Res 2019; 33:e048. https://doi.org/10.1590/1807-3107bor-2019.vol33.0048

Weerheijm KL, Duggal M, Mejàre I, Papagiannoulis L, Koch G, Martens LC, et al. Judgement criteria for molar incisor hypomineralisation (MIH) in epidemiologic studies: a summary of the European meeting on MIH held in Athens, 2003. Eur J Paediatr Dent 2003; 4(3):110-3.

Souza JF, Costa-Silva CM, Jeremias F, Santos-Pinto L, Zuanon AC, Cordeiro RC. Molar incisor hypomineralisation: possible aetiological factors in children from urban and rural areas. Eur Arch Paediatr Dent 2012; 13(4):164-70. https://doi.org/10.1007/bf03262865

Souza JF, Jeremias F, Costa-Silva CM, Santos-Pinto L, Zuanon AC, Cordeiro RC. Aetiology of molar-incisor hypomineralisation (MIH) in Brazilian children. Eur Arch Paediatr Dent 2013; 14:233-8. https://doi.org/10.1007/s40368-013-0054-3

Dantas-Neta NB, Soares Figueiredo M, Lima CCB, Bendo CB, Andrade EMM, Lima MDM, et al. Factors associated with molar-incisor hypomineralisation in schoolchildren aged 8-10 years: a case-control study. Int J Paediatr Dent 2018; 28(6):570-7. https://doi.org/10.1111/ipd.12412

Lygidakis NA, Dimou G, Marinou D. Molar-incisor-hypomineralisation (MIH). A retrospective clinical study in Greek children. II. Possible medical aetiological factors. Eur Arch Paediatr Dent 2008; 9(4):207-17. https://doi.org/10.1007/bf03262637

Allazzam SM, Alaki SM, El Meligy OA. Molar incisor hypomineralization, prevalence, and etiology. Int J Dent 2014; 2014:234508. https://doi.org/10.1155/2014/234508

Pitiphat W, Luangchaichaweng S, Pungchanchaikul P, Angwaravong O, Chansamak N. Factors associated with molar incisor hypomineralization in Thai children. Eur J Oral Sci 2014; 122(4):265-70. https://doi.org/10.1111/eos.12136

Ghanim A, Manton D, Bailey D, Mariño R, Morgan M. Risk factors in the occurrence of molar-incisor hypomineralization amongst a group of Iraqi children. Int J Paediatr Dent 2013; 23(3):197-206. https://doi.org/10.1111/j.1365-263X.2012.01244.x

Fatturi AL, Menezes J, Fraiz FC, Assunção L, de Souza JF. Systemic exposures associated with hypomineralized primary second molars. Pediatr Dent 2019; 41(5):364-70.

Elsori DH, Hammoud MS. Vitamin D deficiency in mothers, neonates and children. J Steroid Biochem Mol Biol 2018; 175:195-9. https://doi.org/10.1016/j.jsbmb.2017.01.023.

van der Tas JT, Elfrink MEC, Heijboer AC, Rivadeneira F, Jaddoe VWV, Tiemeier H, et al. Foetal, neonatal and child vitamin D status and enamel hypomineralization. Community Dent Oral Epidemiol 2018; 46(4):343-51. https://doi.org/10.1111/cdoe.12372

Mejía JD, Restrepo M, González S, Álvarez LG, Santos-Pinto L, Escobar A. Molar incisor hypomineralization in Colombia: prevalence, severity and associated risk factors. J Clin Pediatr Dent 2019; 43(3):185-9. https://doi.org/10.17796/1053-4625-43.3.7

Koruyucu M, Özel S, Tuna EB. Prevalence and etiology of molar-incisor hypomineralization (MIH) in the city of Istanbul. J Dent Sci 2018; 13(4):318-28. https://doi.org/10.1016/j.jds.2018.05.002

Alaluusua S, Lukinmaa PL, Koskimies M, Pirinen S, Hölttä P, Kallio M, et al. Developmental dental defects associated with long breast feeding. Eur J Oral Sci 1996; 104(5-6):493-7. https://doi.org/10.1111/j.1600-0722.1996.tb00131.x

Fagrell TG, Ludvigsson J, Ullbro C, Lundin SA, Koch G. Aetiology of severe demarcated enamel opacities - an evaluation based on prospective medical and social data from 17,000 children. Swed Dent J 2011; 35(2):57-67.

Pinho JRO, Thomaz E, Ribeiro CCC, Alves CMC, Silva A. Factors associated with the development of dental defects acquired in the extrauterine environment. Braz Oral Res 2019; 33:e094. https://doi.org/10.1590/1807-3107bor-2019.vol33.0094

Victora CG, Bahl R, Barros AJ, França GV, Horton S, Krasevec J, et al. Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect. Lancet 2016; 387(10017):475-90. https://doi.org/10.1016/s0140-6736(15)01024-7

Bagattoni S, D'Alessandro G, Prete A, Piana G, Pession A. Oral health and dental late adverse effects in children in remission from malignant disease. A pilot case-control study in Italian children. Eur J Paediatr Dent 2014; 15(1):45-50.

Maguire A, Craft AW, Evans RG, Amineddine H, Kernahan J, Macleod RI, et al. The long-term effects of treatment on the dental condition of children surviving malignant disease. Cancer 1987; 60(10):2570-5.

Pajari U, Lanning M, Larmas M. Prevalence and location of enamel opacities in children after anti-neoplastic therapy. Community Dent Oral Epidemiol 1988; 16(4):222-6. https://doi.org/10.1111/j.1600-0528.1988.tb01759.x

Oğuz A, Cetiner S, Karadeniz C, Alpaslan G, Alpaslan C, Pinarli G. Long-term effects of chemotherapy on orodental structures in children with non-Hodgkin's lymphoma. Eur J Oral Sci 2004; 112(1):8-11. https://doi.org/10.1111/j.0909-8836.2004.00094.x

Whatling R, Fearne JM. Molar incisor hypomineralization: a study of aetiological factors in a group of UK children. Int J Paediatr Dent 2008; 18(3):155-62. https://doi.org/10.1111/j.1365-263X.2007.00901.x

Hong L, Levy SM, Warren JJ, Bergus GR, Dawson DV, Wefel JS, et al. Primary tooth fluorosis and amoxicillin use during infancy. J Public Health Dent 2004; 64(1):38-44. https://doi.org/10.1111/j.1752-7325.2004.tb02724.x

Guergolette RP, Dezan CC, Frossard WT, Ferreira FB, Cerci Neto A, Fernandes KB. Prevalence of developmental defects of enamel in children and adolescents with asthma. J Bras Pneumol 2009; 35(4):295-300. https://doi.org/10.1590/s1806-37132009000400002

Tung K, Fujita H, Yamashita Y, Takagi Y. Effect of turpentine-induced fever during the enamel formation of rat incisor. Arch Oral Biol 2006; 51(6):464-70. https://doi.org/10.1016/j.archoralbio.2005.12.001

Flexeder C, Kabary Hassan L, Standl M, Schulz H, Kühnisch J. Is there an association between asthma and dental caries and molar incisor hypomineralisation? Caries Res 2020; 54(1):87-95. https://doi.org/10.1159/000504382

Elfrink ME, Ghanim A, Manton DJ, Weerheijm KL. Standardised studies on Molar Incisor Hypomineralisation (MIH) and Hypomineralised Second Primary Molars (HSPM): a need. Eur Arch Paediatr Dent 2015; 16(3):247-55. https://doi.org/10.1007/s40368-015-0179-7

Jälevik B, Klingberg GA. Dental treatment, dental fear and behaviour management problems in children with severe enamel hypomineralization of their permanent first molars. Int J Paediatr Dent 2002; 12(1):24-32.