Inibição do crescimento de Staphylococcus aureus por formulação contendo extrato etanólico de barbatimão

Abstract

Barbatimão is a Brazilian species traditionally used to treat vaginal infections. The organisms Staphylococcus aureus, Escherichia coli, and Proteus sp. are present in these infections and may be resistant to treatment. Therefore, the development of formulations that help fight vaginal infections is important. The objective of this study was to develop a formulation containing barbatimão and evaluate its stability and antimicrobial activity. The formulation was prepared using sodium lauryl ether sulfate, amide 90, cocamidopropyl betaine, lactic acid, barbatimão extract, imidazolinidil urea, sodium chloride, menthol, ethyl alcohol, essence, and brown dye. Stability tests were carried out at room temperature (25oC), in a conventional oven (40oC) and in a refrigerator (4oC) for 30 days. The parameters evaluated in the stability tests were color, brightness, odor, pH, and precipitate formation. The minimum inhibitory concentration (MIC) was determined at concentrations between 0.78 and 100% of the formulation. The stability of the oven and refrigerator was tested, and no changes in color, odor, brightness, and pH were observed after 30 days. Viscosity decreased by 10% in the oven test and increased by 5% in the ice-cooler. The formulation inhibited S. aureus growth by 100%. The MIC for Staphylococcus aureus was 25% of the formulation concentration. A formulation containing barbatimão emerges as a promising alternative for treating Staphylococcus aureus infections.